Evidence mapPaperPMID 32290465Full record

ReviewJournal of clinical medicine2020

The Clinical Role of Insulin Degludec/Insulin Aspart in Type 2 Diabetes: An Empirical Perspective from Experience in Australia.

Sarah J Glastras, Neale Cohen, Thomas Dover, Gary Kilov, Richard J MacIsaac, Margaret McGill, Greg R Fulcher

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Sarah J GlastrasDepartment of Diabetes, Endocrinology and Metabolism, The Royal North Shore Hospital, The University of Sydney, Reserve Road, St Leonards, NSW 2065, Australia.ORCID 0000-0002-9317-1348
Neale CohenBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.ORCID 0000-0002-4441-9511
Thomas DoverIpswich General Hospital, Chermside Road, Ipswich, QLD 4305, Australia.
Gary KilovLaunceston Diabetes Clinic, The University of Melbourne, 247 Wellington Street, Launceston, TAS 7250, Australia.
Richard J MacIsaacDepartment of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, The University of Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia.ORCID 0000-0001-8058-6977
Margaret McGillDiabetes Centre, Royal Prince Alfred Hospital, Central Clinical School Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2050, Australia.
Greg R FulcherDepartment of Diabetes, Endocrinology and Metabolism, The Royal North Shore Hospital, The University of Sydney, Reserve Road, St Leonards, NSW 2065, Australia.
The University of Melbourne · AUThe University of Sydney · AUBaker Heart and Diabetes Institute · AURoyal Prince Alfred Hospital · AUThe University of Queensland · AU

Funding

Novo Nordisk -
6 · The paper itself

Abstract

Treatment intensification in people with type 2 diabetes following failure of basal insulin commonly involves the addition of a rapid-acting insulin analogue (basal plus one or more prandial doses; multiple daily injections) or by a switch to premixed insulin. Insulin degludec/insulin aspart (IDegAsp), comprising rapid-acting insulin aspart and ultra-long-acting insulin degludec in solution, enables both fasting and post-prandial glucose control, with some advantages over other treatment intensification options. These include straightforward dose titration, flexibility in dose timing, low injection burden, simplicity of switching and a lower risk of hypoglycaemia. In Australia, where insulin degludec on its own is not available, IDegAsp enables patients to still benefit from its ultra-long-acting properties. This review aims to provide guidance on where and how to use IDegAsp. Specifically, guidance is included on the initiation of IDegAsp in insulin-naïve patients, treatment intensification from basal insulin, switching from premixed or basal-bolus insulin to IDegAsp, up-titration from once- to twice-daily IDegAsp and the use of IDegAsp in special populations or situations.

Indexed as

Australiaco-formulationIDegAspinsulin degludec/insulin asparttype 2 diabetes

Identifiers

PMID32290465
PMCPMC7230791
OpenAlexW3015950237

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.