Evidence map›Paper›PMID 32291286›Full record

ArticleJournal of the American Society of Nephrology : JASN2020

Protein Kinase C-

Jiefu Zhu, Gang Zhang, Zhixia Song, Xiaohong Xiang, Shaoqun Shu, Zhiwen Liu, Danyi Yang, Qingqing Wei, Zheng Dong

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  18. Inhibition of PKC-δ reduce rhabdomyolysis-induced acute kidney injury.Journal of cellular and molecular medicine · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jiefu ZhuDepartment of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China.
Gang ZhangCenter of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, China.
Zhixia SongDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Xiaohong XiangDepartment of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China zdong@augusta.edu.
Shaoqun ShuDepartment of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China.
Zhiwen LiuDepartment of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China.
Danyi YangDepartment of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China.
Qingqing WeiDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Zheng DongDepartment of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China zdong@augusta.edu.
Charlie Norwood VA Medical Center · USSecond Xiangya Hospital of Central South University · CNAugusta University · USCentral South University · CNXiangya Hospital Central South University · CN

Funding

DNA methylation in kidney repair after ischemic AKIR01DK058831 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DONG, ZHENG · 2001 to 2025
$7.5M
Kidney Injury by Cisplatin and Renoprotective Strategies.R01DK087843 · NIDDK · AUGUSTA UNIVERSITY · PI DONG, ZHENG · 2010 to 2025
$5.8M
Molecular Regulation of Ischemic Renal FailureI01BX000319 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI Zheng Dong · 2009 to 2026
–
BLR&D Research Career Scientist Award ApplicationIK6BX005236 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI DONG, ZHENG · 2020 to 2025
–
BLRD VA I01 BX000319BLRD VA IK6 BX005236NIDDK NIH HHS R01 DK058831NIDDK NIH HHS R01 DK087843
6 · The paper itself

Abstract

backgroundKidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C-

methodsTo investigate PKC

resultsWe observed PKC

conclusionsThese results indicate that PKC

Indexed as

Kidney TransplantationAnimalsApoptosisCell DivisionCells, CulturedCold TemperatureDynaminsEnzyme ActivationKidney Tubular Necrosis, AcuteKidney Tubules, ProximalMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaOrgan PreservationDnm1l protein, mouseDynaminsPrkcd protein, mouseProtein Kinase C-deltaProtein Kinase Inhibitorsischemia-reperfusionmitochondriaPKCδ; kidneytransplantation

Identifiers

PMID32291286
PMCPMC7217420
OpenAlexW3015809913

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.