ArticleRice (New York, N.Y.)2020
OsSLC1 Encodes a Pentatricopeptide Repeat Protein Essential for Early Chloroplast Development and Seedling Survival.
Article in Rice (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
- Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications.Journal of integrative plant biology · 2026Review
- Deciphering the regulatory network of carbon isotope discrimination in bread wheat through genome-wide association studies and genomic prediction.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Mapping and Candidate Gene Analysis of the Low-Temperature-Sensitive Albino GeneCurrent issues in molecular biology · 2024Article
- Article
- Characterization of the chloroplast genome of Gleditsia species and comparative analysis.Scientific reports · 2024Article
- PPR proteins in plants: roles, mechanisms, and prospects for rice research.Frontiers in plant science · 2024Review
- OsPPR11 encoding P-type PPR protein that affects group II intron splicing and chloroplast development.Plant cell reports · 2023Article
- Updated Progress on Group II Intron Splicing Factors in Plant Chloroplasts.Current issues in molecular biology · 2022Review
- A chloroplast-localized pentatricopeptide repeat protein involved in RNA editing and splicing and its effects on chloroplast development in rice.BMC plant biology · 2022Article
- Chloroplastic pentatricopeptide repeat proteins (PPR) in albino plantlets of Agave angustifolia Haw. reveal unexpected behavior.BMC plant biology · 2022Article
- Mutation in Mg-Protoporphyrin IX Monomethyl Ester (Oxidative) Cyclase GeneFrontiers in plant science · 2022Article
- An Insight Into Pentatricopeptide-Mediated Chloroplast NecrosisFrontiers in genetics · 2022Article
- An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts.RNA biology · 2022Article
- The nuclear-encoded plastid ribosomal protein L18s are essential for plant development.Frontiers in plant science · 2022Article
- A PPR Protein ACM1 Is Involved in Chloroplast Gene Expression and Early Plastid Development inInternational journal of molecular sciences · 2021Article
- Article
- Fine Mapping of a Novel Major Quantitative Trait Locus,Frontiers in plant science · 2021Article
- Functioning of PPR Proteins in Organelle RNA Metabolism and Chloroplast Biogenesis.Frontiers in plant science · 2021Review
- VIRESCENT-ALBINO LEAF 1 regulates leaf colour development and cell division in rice.Journal of experimental botany · 2018Article
- The rice white green leaf 2 gene causes defects in chloroplast development and affects the plastid ribosomal protein S9.Rice (New York, N.Y.) · 2018Article
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16 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe large family of pentatricopeptide repeat (PPR) proteins is widely distributed among land plants. Such proteins play vital roles in intron splicing, RNA editing, RNA processing, RNA stability and RNA translation. However, only a small number of PPR genes have been identified in rice.
resultsIn this study, we raised a mutant from tissue-culture-derived plants of Oryza sativa subsp. japonica 'Zhonghua 11', which exhibited a lethal chlorosis phenotype from germination to the third-leaf stage. The mutant was designated seedling-lethal chlorosis 1 (slc1). The slc1 mutant leaves showed extremely low contents of photosynthetic pigments and abnormal chloroplast development, and were severely defective in photosynthesis. Map-based cloning of OsSLC1 revealed that a single base (G) deletion was detected in the first exon of Os06g0710800 in the slc1 mutant, which caused a premature stop codon. Knockout and complementation experiments further confirmed that OsSLC1 is responsible for the seedling-lethal chlorosis phenotype in the slc1 mutant. OsSLC1 was preferentially expressed in green leaves, and encoded a chloroplast-localized PPR protein harboring 12 PPR motifs. Loss-of-function of OsSLC1 affected the intron splicing of multiple group II introns, and especially precluded the intron splicing of rps16, and resulted in significant increase in the transcript levels of 3 chloroplast ribosomal RNAs and 16 chloroplast development-related and photosynthesis-related genes, and in significant reduction in the transcript levels of 1 chloroplast ribosomal RNAs and 2 chloroplast development-related and photosynthesis-related genes.
conclusionWe characterized a novel chloroplast-localized PPR protein, OsSLC1, which plays a vital role in the intron splicing of multiple group II introns, especially the rps16 intron, and is essential for early chloroplast development and seedling survival in rice.
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