Evidence mapPaperPMID 32297804Full record

ArticleJournal of diabetes science and technology2021

Machine Learning-Based Adherence Detection of Type 2 Diabetes Patients on Once-Daily Basal Insulin Injections.

Daniel N Thyde, Ali Mohebbi, Henrik Bengtsson, Morten Lind Jensen, Morten Mørup

Open access · hybridAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. A Review on Deep Learning for Quality of Life Assessment Through the Use of Wearable Data.IEEE open journal of engineering in medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel N ThydeDepartment of Applied Mathematics and Computer Science, DTU Compute, Kgs. Lyngby, Denmark.ORCID 0000-0002-0391-0646
Ali MohebbiDepartment of Applied Mathematics and Computer Science, DTU Compute, Kgs. Lyngby, Denmark.ORCID 0000-0001-7705-9332
Henrik BengtssonNovo Nordisk A/S, Device R&D, Hillerød, Denmark.
Morten Lind JensenNovo Nordisk A/S, Medical & Science, Søborg, Denmark.
Morten MørupDepartment of Applied Mathematics and Computer Science, DTU Compute, Kgs. Lyngby, Denmark.
Novo Nordisk (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLack of treatment adherence can lead to life-threatening health complications for people with type 2 diabetes (T2D). Recent improvements and availability in continuous glucose monitoring (CGM) technology have enabled various possibilities to monitor diabetes treatment. Detection of missed once-daily basal insulin injections can be used to provide feedback to patients, thus improving their diabetes management. In this study, we explore how

methodsIn-silico CGM data were generated to simulate a cohort of T2D patients on once-daily insulin injection (Tresiba®).

resultsThe adherence detection accuracy improved as more CGM data became available on the day of classification. The three classification models based on expert-engineered features obtained mean accuracies of 78.6%, 78.2%, and 78.3%. The classification model based purely on learned features obtained a mean accuracy of 79.7%. The two classification models fusing expert-engineered and learned features obtained mean accuracies of 79.7% and 79.8%. All the mentioned results were obtained 16 hours after time of injection.

conclusionThe results suggest that adherence detection based on CGM data is feasible. Even though our study based on in-silico data indicates only slightly improved performance of more complex models, the question remains whether advanced models would outperform the simple in a real-world setting. Thus, future studies on adherence monitoring using real CGM data are relevant.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Blood GlucoseBlood Glucose Self-MonitoringHumansHypoglycemic AgentsInsulinMachine LearningBlood GlucoseHypoglycemic AgentsInsulinadherence detectioncontinuous glucose monitoringdeep learningmachine learningtype 2 diabetesvirtual patient

Identifiers

PMID32297804
PMCPMC7780366
OpenAlexW3016771838

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.