ArticleHuman brain mapping2022
ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia.Biological psychiatry · 2023Pooled it
- Altered lateralization of the cingulum in deployment-related traumatic brain injury: An ENIGMA military-relevant brain injury study.Human brain mapping · 2023Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Schizophrenia bulletin · 2022Pooled it
- Separating Clinical and Subclinical Depression by Big Data Informed Structural Vulnerability Index and Its impact on Cognition: ENIGMA Dot Product.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2022Pooled it
- Suicide attempts, white matter microstructure, and cognitive function in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Disentangling white matter correlates of symptom severity and general impairment in early psychosis.Molecular psychiatry · 2026Article
- Near‑Infrared Photobiomodulation in White‑Matter Disease: From Microglial States to Measurable Endpoints.Neuromolecular medicine · 2026Review
- Lifespan normative modeling of brain microstructure.Nature communications · 2026Article
- Tbx1 heterozygosity in the oligodendrocyte lineage shifts myelinated axon composition in the mouse fimbria without behavioral impairments.Molecular brain · 2026Article
- Biopsychosocial risk factors for Alzheimer's disease and related dementias in UK immigrants from the Middle East and North Africa (MENA).medRxiv : the preprint server for health sciences · 2026Article
- Article
- Identifying transdiagnostic neurobiomarkers for precision major psychiatric disordersJournal of translational internal medicine · 2026Article
- Structural network alterations in adolescent major depression and bipolar disorder: a graph-theoretical and fixel-based analysis.BMC psychiatry · 2026Article
- Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Lifespan Normative Modeling of Brain Microstructure.bioRxiv : the preprint server for biology · 2025Article
- Alzheimer's Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset.Research square · 2025Article
- Toward Big Data-Derived Classification of Neuropsychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Quantitative magnetization transfer and g-ratio imaging of white matter myelin in early psychotic spectrum disorders.Molecular psychiatry · 2025Article
- Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder.JAMA psychiatry · 2025Article
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 9 countries.
Funding
Abstract
The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder-oriented working groups used the ENIGMA-DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and 22q11 deletion syndrome. These deficit patterns are informative of the underlying neurobiology and reproducible in independent cohorts. We reviewed these findings, demonstrated their reproducibility in independent cohorts, and compared the deficit patterns across illnesses. We discussed translating ENIGMA-defined deficit patterns on the level of individual subjects using a metric called the regional vulnerability index (RVI), a correlation of an individual's brain metrics with the expected pattern for a disorder. We discussed the similarity in white matter deficit patterns among SSD, BD, MDD, and OCD and provided a rationale for using this index in cross-diagnostic neuropsychiatric research. We also discussed the difference in deficit patterns between idiopathic schizophrenia and 22q11 deletion syndrome, which is used as a developmental and genetic model of schizophrenia. Together, these findings highlight the importance of collaborative large-scale research to provide robust and reproducible effects that offer insights into individual vulnerability and cross-diagnosis features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.