Evidence map›Paper›PMID 32303829›Full record

Trial reportEuropean journal of applied physiology2020

Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise.

William E Hughes, Nicholas T Kruse, Kenichi Ueda, Andrew J Feider, Satoshi Hanada, Joshua M Bock, Darren P Casey

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

William E HughesDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Nicholas T KruseDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Kenichi UedaDepartment of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Andrew J FeiderDepartment of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Satoshi HanadaDepartment of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Joshua M BockDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Darren P CaseyDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. darren-casey@uiowa.edu.ORCID http://orcid.org/0000-0003-4564-8604
University of Iowa · US

Funding

American Diabetes Association 1-16-1CTA-015
6 · The paper itself

Abstract

purposeBlood flow (BF) and vasodilator responses to knee-extension exercise are attenuated in older adults across an exercise transient (onset, kinetics, and steady-state), and reduced nitric oxide bioavailability (NO) has been hypothesized to be a primary mechanism contributing to this attenuation. We tested the hypothesis acute dietary nitrate (NO

methodsOlder (n = 10) untrained adults performed single and rhythmic knee-extension contractions at 20% and 40% work-rate maximum (WR

resultsAcute ingestion of dietary NO

conclusionsThe key findings of this study are that despite increasing plasma [NO

Indexed as

AgedBlood PressureComposite ResinsDouble-Blind MethodExerciseFemaleFemoral ArteryGlass Ionomer CementsHeart RateHemodynamicsHumansLower ExtremityMaleMuscle ContractionMuscle, SkeletalNitratesComposite ResinsDuet cementGlass Ionomer CementsNitratesAgingBlood flowDietary nitrateNitric oxideVasodilator kinetics

Identifiers

PMID32303829
OpenAlexW3016896045

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.