Evidence map›Paper›PMID 32304391›Full record

ReviewCurrent opinion in endocrinology, diabetes, and obesity2020

Update on in-vivo preclinical research models in adrenocortical carcinoma.

Adwitiya Kar, Margaret E Wierman, Katja Kiseljak-Vassiliades

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in endocrinology, diabetes, and obesity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Adwitiya KarDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus Aurora.
Margaret E WiermanDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus Aurora.
Katja Kiseljak-VassiliadesDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus Aurora.
University of Colorado Anschutz Medical Campus · US

Funding

Identifying and Characterizing Therapeutic Targets in Adrenal CancerK08CA222620 · NCI · UNIVERSITY OF COLORADO DENVER · PI KISELJAKVASSILIADES, KATJA · 2018 to 2022
$1.0M
Targeting Kinases in Novel Preclinical Models of Adrenocortical CarcinomaI01BX004665 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI KISELJAKVASSILIADES, KATJA, WIERMAN, MARGARET E · 2019 to 2024
–
BLRD VA I01 BX004665NCI NIH HHS K08 CA222620
6 · The paper itself

Abstract

purpose of reviewThe aim of this review is to summarize recent advances on development of in vivo preclinical models of adrenocortical carcinoma (ACC). RECENT

findingsSignificant progress has been achieved in the underlying molecular mechanisms of adrenocortical tumorigenesis over the last decade, and recent comprehensive profiling analysis of ACC tumors identified several genetic and molecular drivers of this disease. Therapeutic breakthroughs, however, have been limited because of the lack of preclinical models recapitulating the molecular features and heterogeneity of the tumors. Recent publications on genetically engineered mouse models and development of patient-derived ACC xenografts in both nude mice and humanized mice now provide researchers with novel tools to explore therapeutic targets in the context of heterogeneity and tumor microenvironment in human ACC. SUMMARY: We review current in-vivo models of ACC and discuss potential therapeutic opportunities that have emerged from these studies.

Indexed as

Disease Models, AnimalAdrenal Cortex NeoplasmsAdrenocortical CarcinomaAnimalsCell Transformation, NeoplasticDrug Screening Assays, AntitumorHumansMiceMice, NudeTumor MicroenvironmentXenograft Model Antitumor Assays

Identifiers

PMID32304391
PMCPMC8103733
OpenAlexW3017262211

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.