ArticleTheranostics2020
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Open access · goldAbstract read
In one paragraph
Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 230 citations in OpenAlex.
- Inhibitors of soluble epoxide hydrolase on acute lung injury: a meta-analysis of preclinical studies.Inflammopharmacology · 2022Pooled it
- PTUPB improves cognitive function in Alzheimer's disease associated with enhancing cerebral vascular myogenic response and attenuating vascular remodeling.GeroScience · 2026Article
- E-cigarette aerosol exposure modulates crystalline silica-induced fibrotic responses in the lungs.Archives of toxicology · 2026Article
- Ethanolic Extract ofAntioxidants (Basel, Switzerland) · 2026Article
- NINJ1 plays a vital role in the release of neutrophil extracellular traps during acute lung injury.Cell death & disease · 2026Article
- PTUPB, a soluble epoxide hydrolase/cyclooxygenase‑2 dual inhibitor, reduces endothelial‑to‑mesenchymal transition and improves doxorubicin‑induced vascular and cardiac toxicity.Molecular medicine reports · 2026Article
- Spil-mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Article
- sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney disease.Frontiers in immunology · 2026Article
- MicroRNA-223/NE Signaling Pathway Inhibits Lipopolysaccharide-Induced Acute Lung Injury by Regulating Neutrophil Extracellular Traps.Mediators of inflammation · 2026Article
- MultiZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Cepharanthine alleviates lipopolysaccharide-induced acute lung injury through modulating macrophage polarization.Scientific reports · 2025Article
- PCSK9 Promotes Platelet Activation and NET Formation, Aggravating Pulmonary Microthrombosis in Sepsis-Induced Lung Injury.Biomedicines · 2025Article
- Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice.European journal of pharmacology · 2025Article
- Integrative transcriptomic analysis reveals cross-species conserved core genes and pathways in alveolar macrophages during ALI/ARDS.BMC pulmonary medicine · 2025Article
- The emerging role of microbiota in lung cancer: a new perspective on lung cancer development and treatment.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Citri Sarcodactylis Fructus Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammation and Inflammasome Activation.Food science & nutrition · 2025Article
- Targeted soluble epoxide hydrolase inhibits M1 macrophage polarization to improve cartilage injury in temporomandibular joint osteoarthritis.Journal of translational medicine · 2025Article
- Protective mechanisms of exosomes derived from human umbilical cord mesenchymal stem cells in bronchopulmonary dysplasia.Physiological research · 2025Article
- CDDO-imidazolide ameliorates sepsis-induced ARDS by enhancing mitophagy via the Nrf2 pathway to prohibit alveolar macrophage pyroptosis and HMGB1 release.Acta biochimica et biophysica Sinica · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Hui-Hui YangDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Jia-Xi DuanDepartment of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Shao-Kun LiuDepartment of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Jian-Bing XiongDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Xin-Xin GuanDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Wen-Jing ZhongDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Chen-Chen SunDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Chen-Yu ZhangDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Xiao-Qin LuoDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Yan-Feng ZhangDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Ping ChenDepartment of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Bruce D HammockDepartment of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Sung Hee HwangDepartment of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Jian-Xin JiangState Key Laboratory of Trauma, Burns, and Combined Injury, Army Medical University, Chongqing, 400038, China.
Yong ZhouDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Cha-Xiang GuanDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNUC Davis Comprehensive Cancer CenterUniversity of California, Davis · US
Funding
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1MHYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0MNIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710
Abstract
PubMed holds no abstract for this paper.
Indexed as
Acute Lung InjuryAnimalsCells, CulturedCyclooxygenase 2Cyclooxygenase 2 InhibitorsDisease Models, AnimalEnzyme InhibitorsEpoxide HydrolasesInflammasomesLipopolysaccharidesLungMacrophagesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinCyclooxygenase 2Cyclooxygenase 2 InhibitorsEnzyme InhibitorsEpoxide HydrolasesInflammasomesLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseacute lung injuryCOX-2/sEH dual inhibitorNLRP3 inflammasomeoxidative stress
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.