Evidence map›Paper›PMID 32315831›Full record

ArticleiScience2020

Circulating IgGs in Type 2 Diabetes with Atrial Fibrillation Induce IP

Yanhong Luo, Xian Liu, Ruilian Ma, Yigang Wang, Mark Zimering, Zui Pan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Yanhong LuoDavis Heart and Lung Research Institute, Ohio State University-Wexner Medical Center, Columbus, OH 43210, USA; Department of Endocrinology, The Children's Hospital of Chongqing Medical University, Chongqing, P. R. China.
Xian LiuDepartment of Kinesiology, University of Texas at Arlington, Arlington, TX 76010, USA; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA.
Ruilian MaDivision of Regenerative Medicine Research, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.
Yigang WangDivision of Regenerative Medicine Research, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.
Mark ZimeringEndocrinology, Veterans Affairs New Jersey Healthcare System, East Orange, NJ 07018, USA; Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA. Electronic address: mark.zimering@va.gov.
Zui PanDavis Heart and Lung Research Institute, Ohio State University-Wexner Medical Center, Columbus, OH 43210, USA; Department of Kinesiology, University of Texas at Arlington, Arlington, TX 76010, USA; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA. Electronic address: zui.pan@uta.edu.
The University of Texas at Arlington · USUniversity of Cincinnati · USRutgers, The State University of New Jersey · USThe Ohio State University Wexner Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Higher risk of cardiac arrhythmias including atrial fibrillation (AF) associates with type 2 diabetes mellitus (T2DM) with the underlying mechanism largely unknown. The present study reported a subset of circulating immunoglobulin G autoantibodies (IgGs) from patients with T2DM with AF (T2DM/AF)-induced intracellular calcium elevation in both human induced pluripotent stem cell (iPSC)-derived and mouse atrial cardiomyocytes, whereas (identical concentrations of) IgGs from patients with T2DM without AF could not. The IgG-evoked intracellular calcium elevation was insensitive to verapamil, mibefradil, or BTP-2, indicating calcium source from neither voltage-gated calcium channels nor store-operated calcium entry. On the other hand, pharmacological antagonism or genetic knockdown of inositol triphosphate (IP

Indexed as

Biological SciencesCellular PhysiologyPathophysiologyPhysiology

Identifiers

PMID32315831
PMCPMC7170991
OpenAlexW3015489994

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.