Evidence map›Paper›PMID 32317713›Full record

ArticleScientific reports2020

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1.

Bianca Jupp, Silvia Pitzoi, Enrico Petretto, Adam C Mar, Yolanda Pena Oliver, Emily R Jordan, Stephanie Taylor, Santosh S Atanur, Prashant K Srivastava, Kathrin Saar and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence.International journal of environmental research and public health · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 5 countries.

Bianca Jupp *Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Silvia Pitzoi *MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
Enrico Petretto *MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
Adam C MarDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Yolanda Pena OliverSchool of Psychology, University of Sussex, Brighton, UK.
Emily R JordanDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Stephanie TaylorDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Santosh S AtanurMRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
Prashant K SrivastavaMRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
Kathrin SaarMax Delbruck Centre for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0002-4483-1557
Norbert HubnerMax Delbruck Centre for Molecular Medicine, Berlin, Germany.
Wolfgang H SommerInstitute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5903-6521
Oliver StaehlinInstitute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Rainer SpanagelInstitute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Emma S RobinsonSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine, Institute of Psychiatry, Psychology and Neuroscience, King¹s College, London, UK.
Margarita MorenoDepartment of Psychology & Health Research Centre (CEINSA), University of Almería, Almería, Spain.
Barry J EverittDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4431-6536
Trevor W RobbinsDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0642-5977
Timothy J AitmanCentre for Genomics and Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Edinburgh, UK.
Jeffrey W DalleyDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. jwd20@cam.ac.uk.
University of Cambridge · GBHeidelberg University · DEImperial College London · GBMax Delbrück Center · DEDuke-NUS Medical School · SGInstitute of Genetics and Cancer · GBKing's College London · GBUniversity of Almería · ESUniversity of Bristol · GBUniversity of Sussex · GB

Funding

Medical Research Council G0001354Medical Research Council G0701500Medical Research Council G0802729Medical Research Council G1000183Medical Research Council G1002231Medical Research Council MC_U120061454Medical Research Council MC_U120097112Medical Research Council MR/N02530X/1Wellcome TrustWellcome Trust 093875/Z/10/Z
6 · The paper itself

Abstract

Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified, no study to date has carried out an unbiased, genome-wide approach to identify genetic markers associated with impulsivity in experimental animals. Herein we report a linkage study of a six-generational pedigree of adult rats phenotyped for one dimension of impulsivity, namely premature responding on the five-choice serial reaction time task, combined with genome wide sequencing and transcriptome analysis to identify candidate genes associated with the expression of the impulsivity trait. Premature responding was found to be heritable (h

Indexed as

Quantitative Trait, HeritableAnimalsChromosomes, MammalianFemaleGene Expression RegulationGenetic LinkageGenomeImpulsive BehaviorMalePedigreeQuantitative Trait LociRatsRNA, MessengerTask Performance and AnalysisRNA, Messenger

Identifiers

PMID32317713
PMCPMC7174407
OpenAlexW3016804813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.