ReviewFrontiers in plant science2020
Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics.
Review in Frontiers in plant science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 150 citations in OpenAlex.
- Multi-environment dissection of the genetic architecture of grain color and milling-related recovery traits in foxtail millet.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Microbial Exopolysaccharides, Redox Modulation, and Antioxidant Activity in Fermented Foods.Antioxidants (Basel, Switzerland) · 2026Review
- Tissue-specific metabolomics and pigment profiling of Black Change and red Chal tomatoes.Food chemistry: X · 2026Article
- Phytochemical Analysis and Efficacy Determination of Sargassum cristaefolium Extract Against Aeromonas hydrophila Infection in Labeo rohita Through In Vivo and In Vitro.Current microbiology · 2026Article
- Promiscuous Transferases Malonylate Furaneol Glucoside inJournal of agricultural and food chemistry · 2026Article
- Constitutive Metabolite Profiling of European and Asian Fraxinus with Varying Susceptibility to Ash Dieback.Journal of chemical ecology · 2026Article
- Stomatal conductance dominates the limitation of photosynthetic induction across leaf developmental stages in foxglove.Photosynthesis research · 2025Article
- Synergistic Anticancer Effects of Fermented Noni Extract Combined with 5-Fluorouracil, Doxorubicin, and Vincristine on A549, MCF-7, and SH-SY5Y Cell Models.Current issues in molecular biology · 2025Article
- Glycosylated cannabinoids inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of single and co-cultured lactic acid bacteria on antioxidant capacity and metabolite profiles during rambutan juice fermentation.Food chemistry: X · 2025Article
- Structural Variations of Broccoli Polyphenolics and Their Antioxidant Capacity as a Function of Growing Temperature.Plants (Basel, Switzerland) · 2025Article
- Comprehensive assessment of 3-benzyloxyflavones as β-glucosidase inhibitors:RSC advances · 2025Article
- Article
- Metabolic and Antioxidant Variations in "Regina" Raspberries: A Comparative Analysis of Early and Late Harvests.Plants (Basel, Switzerland) · 2025Article
- Comprehensive metabolome characterization of leaves, internodes, and aerial roots of Vanilla planifolia by untargeted LC-MS and GC × GC-MS.Phytochemical analysis : PCA · 2025Article
- Efficient accumulation of new irregular monoterpene malonyl glucosides inFrontiers in plant science · 2025Article
- Targeting the Molecules in EMT: A Potential Therapeutic Opportunity in Breast Cancer.Current molecular medicine · 2025Review
- Phytochemical Screening and Characterization of Volatile Compounds from Three Medicinal Plants with Reported Anticancer Properties Using GC-MS.Life (Basel, Switzerland) · 2024Article
- Article
- Transcriptomic landscape of seedstick in Arabidopsis thaliana funiculus after fertilisation.BMC plant biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the central theme of the review. The therapeutic value of plant glycosidases is discussed as well as the present production in plant platforms of therapeutic human glycosidases used in enzyme replacement therapies. The increasing knowledge on glycosidases, including structure and catalytic mechanism, is described. The novel insights have allowed the design of functionalized highly specific suicide inhibitors of glycosidases. These so-called activity-based probes allow unprecedented visualization of glycosidases cross-species. Here, special attention is paid on the use of such probes in plant science that promote the discovery of novel enzymes and the identification of potential therapeutic inhibitors and chaperones.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.