Evidence map›Paper›PMID 32320012›Full record

ArticleThe American journal of clinical nutrition2020

Plasma phospholipid very-long-chain SFAs in midlife and 20-year cognitive change in the Atherosclerosis Risk in Communities (ARIC): a cohort study.

Danni Li, Jeffrey R Misialek, Ma Jing, Michael Y Tsai, John H Eckfeldt, Lyn M Steffen, David Knopman, Lisa Wruck, Rebecca Gottesman, Tom H Mosley and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Danni LiDepartment of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN, USA.
Jeffrey R MisialekDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Ma JingDepartment of Population Medicine, Harvard Medical School, Boston, MA, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN, USA.
John H EckfeldtDepartment of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN, USA.
Lyn M SteffenDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
David KnopmanDepartment of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Lisa WruckDuke Clinical Research Institute, Duke University, Durham, NC, USA.
Rebecca GottesmanDepartment of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Tom H MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
A Richey SharrettDepartment of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
University of Minnesota Medical Center · USJohns Hopkins University · USUniversity of Minnesota · USDuke University · USEmory University · USHarvard University · USJackson Memorial Hospital · USMayo Clinic · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Blood Biomarkers as Surrogate Endpoints of Treatment Responses to Aerobic Exercise and/or Cognitive Training in Amnestic Mild Cognitive ImpairmentR01AG059654 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2018 to 2022
$2.2M
Mentoring in patient-oriented atrial fibrillation and cardiovascular researchK24HL148521 · NHLBI · EMORY UNIVERSITY · PI ALONSO, ALVARO · 2019 to 2023
$593k
Identification of plasma hydroxysphingolipids as biomarkers of demyelination and neurodegeneration underlying physical function decline in older adultsR21AG059068 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2018 to 2019
$449k
Identification of proteins in plasma lipoproteins as biomarkers to aid in diagnosing and predicting progression of Alzheimer's disease in older adultsR21AG061372 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2019 to 2020
$448k
NHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS K24 HL148521NHLBI NIH HHS U01 HL096812NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG059654NIA NIH HHS R21 AG059068NIA NIH HHS R21 AG061372
6 · The paper itself

Abstract

backgroundVery-long-chain SFAs (VLSFAs) have recently gained considerable attention as having beneficial effects on health and aging.

objectivesThe objective of this study was to assess the associations of plasma phospholipid VLSFAs [arachidic acid (20:0), behenic acid (22:0), tricosanoic acid (23:0), and lignoceric acid (24:0)] with 20-y cognitive decline in the Atherosclerosis Risk in Communities (ARIC) participants. Furthermore, this study compared the associations of plasma phospholipid VLSFAs with 5 common groups of fatty acids [i.e., total SFAs, total MUFAs, total ω-3 (n-3) PUFAs, total marine-derived ω-3 PUFAs, total ω-6 PUFAs].

methodsThis study used a cohort study design of 3229 ARIC participants enrolled at the Minnesota field center. Fatty acids were measured at visit 1 (1987-1989); and cognition was assessed at visits 2 (1990-1992), 4 (1996-1998), and 5 (2011-2013) using 3 tests: the Delayed Word Recall Test (DWRT), the Digit-Symbol Substitution Test (DSST), and the Word Fluency Test (WFT).

resultsHigher proportions of plasma phospholipid total VLSFAs and each individual VLSFA were associated with less decline in WFT, a test of verbal fluency. For example, 1 SD higher in total VLSFAs at baseline was associated with 0.057 SD (95% CI: 0.018, 0.096, P = 0.004) less cognitive decline over 20 y as measured by WFT score. None of the 5 common fatty acid groups were associated with change in WFT, but a higher proportion of plasma phospholipid total MUFAs was associated with greater decline in DWRT; higher total ω-6 PUFAs with less decline in DWRT; and higher total ω-3 and total marine-derived ω-3 PUFAs with less decline in DSST.

conclusionsThis study suggests that higher proportions of plasma phospholipid VLSFAs in midlife may be associated with less 20-y cognitive decline.

Indexed as

CognitionAgedAtherosclerosisCognition DisordersCohort StudiesEicosanoic AcidsFatty AcidsFatty Acids, UnsaturatedFemaleHumansLongitudinal StudiesMiddle AgedPhospholipidsProspective Studiesarachidic acidbehenic acidEicosanoic AcidsFatty AcidsFatty Acids, Unsaturatedlignoceric acidPhospholipidstricosanoic acidcognitive changeDelayed Word Recall Test (DWRT)Digit-Symbol Substitution Test (DSST)midlifeplasma phospholipid very-long-chain saturated fatty acids (VLSFAs)Word Fluency Test (WFT)

Identifiers

PMID32320012
PMCPMC7266687
OpenAlexW3017213825

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.