Evidence map›Paper›PMID 32321811›Full record

ArticleJournal of virology2020

The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling.

Jorge Vera-Otarola, Loretto Solis, Fernando Lowy, Valeria Olguín, Jenniffer Angulo, Karla Pino, Nicole D Tischler, Carola Otth, Paula Padula, Marcelo López-Lastra

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jorge Vera-OtarolaLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile javochile@gmail.com malopez@med.puc.cl.ORCID 0000-0003-2547-4213
Loretto SolisLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Fernando LowyLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Valeria OlguínLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Jenniffer AnguloLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Karla PinoLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Nicole D TischlerLaboratorio de Virología Molecular, Fundación Ciencia & Vida, Santiago, Chile.
Carola OtthInstituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
Paula PadulaInstituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. C. G. Malbrán, Buenos Aires, Argentina.
Marcelo López-LastraLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile javochile@gmail.com malopez@med.puc.cl.ORCID 0000-0002-7936-8478
Pontificia Universidad Católica de Chile · CLAdministración Nacional de Laboratorios e Institutos de Salud · ARAustral University of Chile · CLSan Sebastián University · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small messenger RNA (SmRNA) of the

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell LineChlorocebus aethiopsHantavirus InfectionsHEK293 CellsHost-Pathogen InteractionsHumansImmunity, InnateInterferon-betaInterferon Regulatory Factor-3Interferon Type INF-kappa BOrthohantavirusProtein Serine-Threonine KinasesSignal TransductionAdaptor Proteins, Signal TransducingInterferon-betaInterferon Regulatory Factor-3Interferon Type IMAVS protein, humanNF-kappa BProtein Serine-Threonine KinasesViral Nonstructural ProteinsANDVIFN-βMAVSMDA5NSs proteinRIG-I

Identifiers

PMID32321811
PMCPMC7307155
OpenAlexW3017979176

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.