Trial reportScientific reports2020
Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Sector-Specific Patterns of RNFL and Ganglion Cell Complex Thinning Across the Myopia Spectrum: A Cross-Sectional OCTA Study.Medicina (Kaunas, Lithuania) · 2026Article
- Objective Macular Asymmetry Metrics for Glaucoma Detection Using a Temporal Raphe-Based OCT Linearization Algorithm.Journal of clinical medicine · 2026Article
- Association of 10-2 Visual Field Cluster Patterns With Visual Acuity in Normal-Tension Glaucoma Patients With Central Visual Field Defects.Investigative ophthalmology & visual science · 2025Article
- The Significance of OCTA in Studying Vessel Density and Retinal Thickness in Individuals with Myopia.Medicina (Kaunas, Lithuania) · 2025Article
- Early changes in photopic negative response in eyes with glaucoma with and without choroidal detachment after filtration surgery.The British journal of ophthalmology · 2023Observational
- Reduced intradisc vessel density is associated with optic disc hemorrhage in eyes with primary open-angle glaucoma.Scientific reports · 2023Article
- Association of macular structure, function, and vessel density with foveal threshold in advanced glaucoma.Scientific reports · 2022Article
- Relationship Between Deep Retinal Macular Vessel Density and Bipolar Cell Function in Glaucomatous Eyes.Translational vision science & technology · 2022Article
- Longitudinal Macular Retinal and Choroidal Microvasculature Changes in High Myopia.Investigative ophthalmology & visual science · 2021Article
- Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source optical coherence tomography angiography (SS-OCTA), and its relationship with the central visual field (VF) loss. Thirty-four eyes of 27 patients with open-angle glaucoma were included. SS-OCTA macular scanning was performed within a 3 × 3 mm (300 × 300 pixels) volume, centred on the fovea. The relationships between the vertical asymmetrical deep retinal vessel density reduction (ADRVD) across the temporal raphe and various ocular parameters were analysed. Twenty-two glaucomatous eyes with ADRVDs had central VF loss. Contrarily, ADRVDs were not found in any of the 12 eyes without central VF loss. Thirteen eyes (59.1%) with central VF loss had ADRVDs topographically corresponding to the central VF loss and macular ganglion cell complex thinning. The glaucomatous eyes with ADRVDs exhibited inferior rather than superior central VF loss (P = 0.032). Thus, ADRVD specifically indicates the glaucomatous central visual loss. Further analysis of ADRVD may improve our understanding on glaucoma pathogenesis, offering new treatment insights.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.