Evidence map›Paper›PMID 32323264›Full record

SynthesisMolecular biology reports2020

Association of the polymorphisms of the genes APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) with lipodystrophy in people living with HIV on antiretroviral therapy: a systematic review.

Andreia Soares da Silva, Tatiana Lins Carvalho, Kleyton Palmeira do Ó, Débora Nascimento da Nóbrega, Roberta Dos Santos Souza, Victor Fernando da Silva Lima, Isabela Cristina Cordeiro Farias, Taciana Furtado de Mendonça Belmont, Maria do Socorro de Mendonça Cavalcanti, Demócrito de Barros Miranda-Filho

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Andreia Soares da SilvaFaculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil. andreiasoares.upe@hotmail.com.
Tatiana Lins CarvalhoHospital Universitário Oswaldo Cruz (HUOC), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Kleyton Palmeira do ÓInstituto de Pesquisa Aggeu Magalhães (CPqAM), Fundação Oswaldo Cruz (FIOCRUZ), Recife, PE, Brazil.
Débora Nascimento da NóbregaInstituto de Ciências Biológicas (ICB), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Roberta Dos Santos SouzaInstituto de Ciências Biológicas (ICB), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Victor Fernando da Silva LimaFaculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Isabela Cristina Cordeiro FariasFaculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Taciana Furtado de Mendonça BelmontFaculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Maria do Socorro de Mendonça CavalcantiFaculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Demócrito de Barros Miranda-FilhoFaculdade de Ciências Médicas (FCM), Universidade de Pernambuco (UPE), Recife, PE, Brazil.
Universidade de Pernambuco · BRFundação Oswaldo Cruz · BRHospital Universitário Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to perform a systematic review to identify data reported in the literature concerning the association of APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) polymorphisms with lipodystrophy in people living with HIV (PLWHIV) on antirretroviral therapy. The research was conducted in six databases and the studies were selected in two steps. First, a search was undertaken in the following electronic databases: PubMed, Science Direct, Medline, World Wide Science, Directory of Open Access Journals, Scielo, Lilacs and Medcarib. The titles and abstracts of 24,859 articles were read to select those that match the elegibilty criteria. Five papers that addressed the association of HAART, lipodystrophy and polymorphisms were selected for the review. There was no association between the polymorphisms of the genes APOC3 and PPARG and lipodystrophy. Another study described an association between the variant allele (G) of HFE and protection concerning the development of lipoatrophy (0.02) when compared with the reference allele (C). On the other hand, the variant allele (T) of the ESR2 gene was associated with the development of lipoatrophy (p = 0.007) when compared with the reference allele (C). In addition, the genotype and the variant allele of the gene MMP1 (2G) were associated with lipodystrophy in PLWHIV on HAART (p = 0.0002 and p = 0.0008, respectively). Therefore, further studies with other populations, involving PLWHIV on HAART are necessary to better understand the role of genetic markers, which may be involved in a predisposition to lipodystrophy.

Indexed as

Apolipoprotein C-IIIEstrogen Receptor betaFemaleGene FrequencyGenetic Association StudiesGenotypeHemochromatosis ProteinHIVHIV-Associated Lipodystrophy SyndromeHIV InfectionsHumansLipodystrophyMaleMatrix Metalloproteinase 1Polymorphism, Single NucleotidePPAR gammaAPOC3 protein, humanApolipoprotein C-IIIEstrogen Receptor betaHemochromatosis ProteinHFE protein, humanMatrix Metalloproteinase 1MMP1 protein, humanPPAR gammaPPARG protein, humanAntiretroviral therapyAPOC3ESR2HFEHIVMMP1PolymorphismsPPARG

Identifiers

PMID32323264
OpenAlexW3018095330

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.