ArticleMolecular medicine reports2020
ATG7 promotes autophagy in sepsis‑induced acute kidney injury and is inhibited by miR‑526b.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- circGAB1 Activates Autophagy to Promote Sepsis-Associated Acute Kidney Injury by Interacting with ELAVL1 to Activate the HMGB3/β-catenin Signaling Pathway.Applied biochemistry and biotechnology · 2026Article
- Probiotic co-administration attenuates developmental cafeteria diet-induced cellular stress and NLRP3 inflammasome signaling in the spleen.Frontiers in nutrition · 2026Article
- Review
- A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway.Journal of advanced research · 2025Article
- Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases.Communications biology · 2024Review
- miR-506-3p induces autophagy of renal tubular epithelial cells in sepsis through targeting PI3K pathway.Aging · 2023Article
- Downregulation of miR-527 alleviates sepsis-induced acute kidney injury via targeting Beclin1.Histology and histopathology · 2023Article
- Article
- MicroRNAs in septic acute kidney injury.Burns & trauma · 2023Article
- Epigenetic dysregulation of autophagy in sepsis-induced acute kidney injury: the underlying mechanisms for renoprotection.Frontiers in immunology · 2023Review
- Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury.Frontiers in physiology · 2022Review
- SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation.Cell death & disease · 2021Article
- Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway.Journal of inflammation (London, England) · 2021Article
- Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is considered to be the most common contributing factor in the development of acute kidney injury (AKI). However, the mechanisms by which sepsis leads to AKI remain unclear. Autophagy is important for a number of fundamental biological activities and plays a key role in numerous different diseases. The present study demonstrated that autophagy is involved in sepsis‑induced kidney injury and upregulates ATG7, LC3 and Beclin I. In addition, it was revealed that miR‑526b is decreased in sepsis‑induced kidney injury, and miR‑526b was identified as a direct regulator of ATG7. Furthermore, the present study investigated the biological effects of ATG7 inhibited by miR‑526b and demonstrated that miR‑526b could promote cell viability by inhibiting autophagy, potentially through targeting ATG7. In conclusion, the present study highlights the role of autophagy in sepsis‑induced AKI, and miR‑526b in regulating autophagy through targeting ATG7, which suggested that miR‑526b may be a molecular therapeutic target for sepsis‑induced AKI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.