Evidence map›Paper›PMID 32325720›Full record

ArticleInternational journal of molecular sciences2020

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory.

Yu-Nung Lin, Gilbert Audira, Nemi Malhotra, Nguyen Thi Ngoc Anh, Petrus Siregar, Jen-Her Lu, Hsinyu Lee, Chung-Der Hsiao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yu-Nung LinDepartment of Life Science, National Taiwan University, Taipei 11221, Taiwan.
Gilbert AudiraDepartment of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Nemi MalhotraDepartment of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Nguyen Thi Ngoc AnhDepartment of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Petrus SiregarDepartment of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Jen-Her LuDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei 11221, Taiwan.ORCID 0000-0003-2056-3065
Hsinyu LeeDepartment of Life Science, National Taiwan University, Taipei 11221, Taiwan.ORCID 0000-0002-1477-0183
Chung-Der HsiaoDepartment of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.ORCID 0000-0002-6398-8672
Chung Yuan Christian University · TWNational Taiwan University · TWNational Yang Ming Chiao Tung University · TW

Funding

Ministry of Science Techmology, Taiwan 107-2622-B-033-001-CC2; 108-2622-B-033-001-CC2
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a small lysophospholipid molecule that activates multiple cellular functions through pathways with G-protein-coupled receptors. So far, six LPA receptors (LPAR1 to LPAR6) have been discovered and each one of them can connect to the downstream cell message-transmitting network. A previous study demonstrated that LPA receptors found in blood-producing stem cells can enhance erythropoietic processes through the activation of LPAR3. In the current study, newly discovered functions of LPAR3 were identified through extensive behavioral tests in

Indexed as

Memory, Short-TermAggressionAnimalsAnimals, Genetically ModifiedAnxietyAvoidance LearningBehavior Rating ScaleBrainCircadian RhythmColor Perception TestsEnzyme-Linked Immunosorbent AssayExploratory BehaviorGene Expression RegulationGene Knockout TechniquesHormonesLocomotionHormonesNeurotransmitter AgentsReceptors, Lysophosphatidic Acidanxietybehaviorcircadian rhythm locomotor activitylysophosphatidic acid receptormemoryzebrafish

Identifiers

PMID32325720
PMCPMC7215700
OpenAlexW3016336738

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.