Evidence map›Paper›PMID 32325968›Full record

ArticleNutrients2020

The Combination Effect of Aspalathin and Phenylpyruvic Acid-2-

Phiwayinkosi V Dludla, Christo J F Muller, Johan Louw, Sithandiwe E Mazibuko-Mbeje, Luca Tiano, Sonia Silvestri, Patrick Orlando, Fabio Marcheggiani, Ilenia Cirilli, Nireshni Chellan and 5 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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  5. Pharmaceuticals (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Phiwayinkosi V DludlaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Christo J F MullerBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Johan LouwBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Sithandiwe E Mazibuko-MbejeBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Luca TianoDepartment of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Sonia SilvestriDepartment of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Patrick OrlandoDepartment of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Fabio MarcheggianiDepartment of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Ilenia CirilliDepartment of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
Nireshni ChellanBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Samira GhoorBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Bongani B NkambuleSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
M Faadiel EssopCentre for Cardio-metabolic Research in Africa, Department of Physiological Sciences, Stellenbosch University, Stellenbosch 7600, South Africa.
Barbara HuisamenBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Rabia JohnsonBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
South African Medical Research Council · ZAMarche Polytechnic University · ITStellenbosch University · ZAUniversità di Camerino · ITUniversity of KwaZulu-Natal · ZA

Funding

Developing Research Innovation, Localization and Leadership in South Africa (DRILL)D43TW010131 · FIC · UNIVERSITY OF KWAZULU-NATAL · PI BRYSIEWICZ, PETRA, MOSHABELA, MOSA · 2015 to 2019
$3.2M
FIC NIH HHS D43 TW010131National Research Foundiation (ZA) 117829 and 87836
6 · The paper itself

Abstract

Recent evidence shows that rooibos compounds, aspalathin and phenylpyruvic acid-2-

Indexed as

AMP-Activated Protein Kinase KinasesAnimalsAspalathusCells, CulturedChalconesDNA DamageEnergy MetabolismGene ExpressionGlucoseGlucosidesMembrane Potential, MitochondrialMetforminMyocytes, CardiacNADPH OxidasesOxidative StressPhenylpyruvic AcidsAMP-Activated Protein Kinase KinasesaspalathinChalconesGlucoseGlucosidesMetforminNADPH Oxidasesphenylpyruvic acidPhenylpyruvic AcidsPPAR alphaProtein KinasesReactive Oxygen Speciesapoptosisaspalathindiabeteshyperglycemiaoxidative stressphenylpropenoic acid glucosiderooibos

Identifiers

PMID32325968
PMCPMC7231041
OpenAlexW3016644007

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.