Evidence map›Paper›PMID 32326049›Full record

ReviewInternational journal of molecular sciences2020

Bioinformatics Methods for Mass Spectrometry-Based Proteomics Data Analysis.

Chen Chen, Jie Hou, John J Tanner, Jianlin Cheng

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed.

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  7. Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026
    Article
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  20. CENPF as a prognostic marker of glioma: unraveling the molecular mechanisms.Journal of cancer research and clinical oncology · 2025
    Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chen ChenDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.
Jie HouDepartment of Computer Science, Saint Louis University, St. Louis, MO 63103, USA.
John J TannerDepartments of Biochemistry and Chemistry, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0001-8314-113X
Jianlin ChengDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.

Funding

Integrated Prediction of Protein Struture at 1D, 2D and 3D LevelsR01GM093123 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHENG, JIANLIN · 2010 to 2023
$3.8M
National Science Foundation DBI1759934National Science Foundation IIS1763246NIH HHS R01GM093123
6 · The paper itself

Abstract

Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous progress in the understanding of cellular mechanisms, disease progression, and the relationship between genotype and phenotype. Though many popular bioinformatics methods in proteomics are derived from other omics studies, novel analysis strategies are required to deal with the unique characteristics of proteomics data. In this review, we discuss the current developments in the bioinformatics methods used in proteomics and how they facilitate the mechanistic understanding of biological processes. We first introduce bioinformatics software and tools designed for mass spectrometry-based protein identification and quantification, and then we review the different statistical and machine learning methods that have been developed to perform comprehensive analysis in proteomics studies. We conclude with a discussion of how quantitative protein data can be used to reconstruct protein interactions and signaling networks.

Indexed as

Computational BiologyData AnalysisMass SpectrometryProteomicsHumansMachine LearningProtein Interaction MappingProtein Interaction MapsWorkflowbioinformatics analysiscomputational proteomicsmachine learning

Identifiers

PMID32326049
PMCPMC7216093

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.