Evidence map›Paper›PMID 32328067›Full record

ArticleFrontiers in immunology2020

CD4

Rune A Høglund, Robert D Bremel, E Jane Homan, Silje Bøen Torsetnes, Andreas Lossius, Trygve Holmøy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Plasma IgG aggregates as biomarkers for multiple sclerosis.Clinical immunology (Orlando, Fla.) · 2023
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rune A HøglundDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Robert D BremelioGenetics LLC, Madison, WI, United States.
E Jane HomanioGenetics LLC, Madison, WI, United States.
Silje Bøen TorsetnesDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Andreas LossiusDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Trygve HolmøyDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Akershus University Hospital · NOioGenetics (United States) · USUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cells are important pathogenic players in multiple sclerosis (MS), but their exact role is not known. We have previously demonstrated that B cells from cerebrospinal fluid (CSF) of MS patients can activate T cells that specifically recognize antigenic determinants (idiotopes) from their B cell receptors (BCRs). The aim of this study was to evaluate whether

Indexed as

B-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell CommunicationCerebrospinal FluidEpitopes, B-LymphocyteHumansImmunologic MemoryMultiple SclerosisReceptors, Antigen, B-CellReceptors, CCR6CCR6 protein, humanEpitopes, B-LymphocyteReceptors, Antigen, B-CellReceptors, CCR6B cellepitope predictionidiotopeIGHVmultiple sclerosisT-B collaborationT cellTh17

Identifiers

PMID32328067
PMCPMC7160327
OpenAlexW3015997945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.