ArticleInternational journal of molecular sciences2020
Differential Expression and Function of Bicellular Tight Junctions in Skin and Oral Wound Healing.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective.International journal of molecular sciences · 2022Pooled it
- Aquaporin 3 Promoter Polymorphisms Reduce Gene Expression and Associate Altered Autophagy-Related Gene Signatures With Atopic Dermatitis Susceptibility.Experimental dermatology · 2026Article
- Review
- Fungal Reactive Oxygen Species Secreted byJournal of fungi (Basel, Switzerland) · 2026Article
- FGFR2 identified as a NETs-associated biomarker and therapeutic target in diabetic foot ulcers.European journal of medical research · 2025Article
- Transcriptomic Differences Between Immortalized Oral and Skin Keratinocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Physiologically relevant coculture model for oral microbial-host interactions.International journal of oral science · 2025Article
- PVA and PVP nanofibers combined with Helichrysum italicum oil preserve skin cell interactions, elasticity and proliferation.Scientific reports · 2025Article
- Differential Temperature-Induced Responses in Immortalized Oral and Skin Keratinocytes.International journal of molecular sciences · 2025Article
- Pinoresinol enhances oral barrier integrity and function in human buccal cell monolayers.PloS one · 2025Article
- Sequencing of messenger RNA in the healing process of diabetes foot ulcer.Frontiers in endocrinology · 2024Article
- Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders.Dermatopathology (Basel, Switzerland) · 2023Article
- Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine.Materials today. Bio · 2023Review
- Mechanical Regulation of Oral Epithelial Barrier Function.Bioengineering (Basel, Switzerland) · 2023Article
- Exploring body weight-influencing gut microbiota by elucidating the association with diet and host gene expression.Scientific reports · 2023Article
- Bioconversion of BIOGF1K, a compound-K-rich fraction from ginseng root and its effect on epidermal barrier function.Heliyon · 2023Article
- Structure-activity relationship of a peptide permeation enhancer.Tissue barriers · 2023Article
- Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing.Cold Spring Harbor perspectives in biology · 2022Review
- An Overview of Physical, Microbiological and Immune Barriers of Oral Mucosa.International journal of molecular sciences · 2021Review
- A critical role of AREG for bleomycin-induced skin fibrosis.Cell & bioscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bicellular tight junctions are multiprotein complexes that are required for maintenance of barrier function and fence function in epithelial tissues. Wound healing in the oral cavity leads to minimal scar formation compared to the skin, and the precise mechanisms for this regenerative response remain to be elucidated. We hypothesized that oral and skin tissues express a different tight junction repertoire both at baseline and during the wound healing response, and that these molecules may be critical to the differential repair between the two tissues. We re-analyzed a mouse skin and palate epithelium microarray dataset to identify the tight junction repertoire of these tissue types. We then re-analyzed a skin and tongue wound healing microarray dataset to see how expression levels of tight junction genes change over time in response to injury. We performed in vitro scratch assays on human oral and skin keratinocyte cell lines to assay for tight junction expression over time, tight junction expression in response to lipopolysaccharide and histamine treatment, and the effects of siRNA knockdown of claudin 1 or occludin on migration and proliferation. Our data showed that oral and skin epithelium expressed different tight junction genes at baseline and during the wound healing response. Knockdown of claudin 1 or occludin led to changes in proliferation and migration in human skin keratinocytes but not oral keratinocytes. Furthermore, we also showed that skin keratinocytes were more permeable than oral keratinocytes upon histamine treatment. In conclusion, this study highlights a specific subset of functional tight junction genes that are differentially expressed between the oral and skin tissues, which may contribute to the mechanisms leading to distinct healing phenotypes in response to injury in the two tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.