Evidence map›Paper›PMID 32341083›Full record

ArticleMolecular and cellular biology2020

Active Replication Checkpoint Drives Genome Instability in Fission Yeast

Seong Min Kim, Susan L Forsburg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Making Choices: DNA Replication Fork Recovery Mechanisms.Seminars in cell & developmental biology · 2021
    Review
  4. MonitoringBiology open · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Seong Min KimMolecular and Computational Biology, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-8328-8211
Susan L ForsburgMolecular and Computational Biology, University of Southern California, Los Angeles, California, USA forsburg@usc.edu.ORCID 0000-0002-4895-8598
University of Southern California · US

Funding

Mechanisms linking replication stress to genome instability in fission yeastR35GM118109 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 2016 to 2025
$7.1M
NIGMS NIH HHS R35 GM118109
6 · The paper itself

Abstract

Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However, we find that the response is different in temperature-sensitive

Indexed as

Cell Cycle CheckpointsCheckpoint Kinase 2DNA DamageDNA, FungalDNA ReplicationGenome, FungalGenomic InstabilityMinichromosome Maintenance Complex Component 4MutationSchizosaccharomycesSchizosaccharomyces pombe ProteinsCds1 protein, S pombeCheckpoint Kinase 2DNA, Fungalmcm4 protein, S pombeMinichromosome Maintenance Complex Component 4Schizosaccharomyces pombe ProteinsCds1checkpoint kinaseChk1fission yeastgenome stabilitymcm4Mus81replication stress

Identifiers

PMID32341083
PMCPMC7324846
OpenAlexW3017893816

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.