Evidence map›Paper›PMID 32345636›Full record

ArticlemBio2020

APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1.

Mollie M McDonnell, Kate H D Crawford, Adam S Dingens, Jesse D Bloom, Michael Emerman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mollie M McDonnellMolecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA.
Kate H D CrawfordDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Adam S DingensDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Jesse D BloomDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.ORCID 0000-0003-1267-3408
Michael EmermanDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA memerman@fredhutch.org.ORCID 0000-0002-4181-6335
Fred Hutch Cancer Center · USHoward Hughes Medical Institute · USUniversity of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
X-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANKEL, ALAN D · 2019 to 2021
$14.4M
VPR AND HIV INFECTIONR01AI030927 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EMERMAN, MICHAEL · 1991 to 2020
$5.3M
Complete mapping of immune selection from antibodies to HIVR01AI140891 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2019 to 2024
$2.4M
Complete mapping of the functional and antigenic effects of mutations to Lassa virus glycoproteinF30AI149928 · NIAID · UNIVERSITY OF WASHINGTON · PI CRAWFORD, KATHARINE HOLT DUSENBURY · 2020 to 2021
$91k
Howard Hughes Medical InstituteNIAID NIH HHS F30 AI149928NIAID NIH HHS P50 AI150476NIAID NIH HHS R01 AI030927NIAID NIH HHS R01 AI140891NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins,

Indexed as

Antiviral AgentsCytidine DeaminaseDNA Restriction EnzymesHIV-1Humansvif Gene Products, Human Immunodeficiency VirusAntiviral AgentsAPOBEC3C protein, humanCytidine DeaminaseDNA Restriction Enzymesvif Gene Products, Human Immunodeficiency Virusvif protein, Human immunodeficiency virus 1APOBEC3CHIV-1innate immunityrestriction factorVif

Identifiers

PMID32345636
PMCPMC7188997
OpenAlexW3020343692

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.