Evidence map›Paper›PMID 32348501›Full record

ArticleJournal of the National Cancer Institute2021

Strategies to Prevent or Remediate Cancer and Treatment-Related Aging.

Jennifer L Guida, Tanya Agurs-Collins, Tim A Ahles, Judith Campisi, William Dale, Wendy Demark-Wahnefried, Jorg Dietrich, Rebecca Fuldner, Lisa Gallicchio, Paige A Green and 17 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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  8. Cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a longitudinal feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 16 institutions in 1 country.

Jennifer L GuidaDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Tanya Agurs-CollinsDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Tim A AhlesDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Judith CampisiBuck Institute for Research on Aging, Novato, CA, USA.
William DaleCity of Hope, Duarte, CA, USA.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama, Birmingham, AL, USA.
Jorg DietrichDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rebecca FuldnerDivision of Aging Biology, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Lisa GallicchioDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Paige A GreenDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Arti HurriaCity of Hope, Duarte, CA, USA.
Michelle C JanelsinsDepartment of Surgery and Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Chamelli JhappanDivision of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
James L KirklandRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Ronald KohanskiDivision of Aging Biology, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Valter LongoUniversity of Southern California, Los Angeles, California, USA.
Simin MeydaniJean Mayer USDA Human Nutritional Research Center on Aging, Tufts University, Boston, MA, USA.
Supriya MohileDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Laura J NiedernhoferDepartment of Biochemistry, Molecular Biology, and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
Christian NelsonDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Frank PernaDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Keri SchadlerDepartment of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.
Jessica M ScottMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Jennifer A SchrackDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Russell P TracyDepartments of Pathology & Laboratory Medicine, and Biochemistry, Larner College of Medicine, University of Vermont, Colchester, VT, USA.
Jan van DeursenMayo Clinic, Rochester, MN, USA.
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
National Institutes of Health · USMemorial Sloan Kettering Cancer Center · USCity of Hope · USUniversity of Rochester Medical Center · USBuck Institute for Research on Aging · USJohns Hopkins University · USMassachusetts General Hospital · USMayo Clinic in Arizona · USMayo Clinic in Florida · USSt. Jude Children's Research Hospital · USThe University of Texas MD Anderson Cancer Center · USTufts University · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · USUniversity of Southern California · USUniversity of Vermont · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Bao Q Vuong · 2008 to 2026
$28.9M
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Zhengdong Zhang · 2017 to 2026
$24.5M
Metabolic Adaptations to Two Year Caloric RestrictionU01AG020478 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RAVUSSIN, ERIC · 2002 to 2008
$13.4M
PROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2M
Caloric Restriction and Aging in HumansU01AG020487 · NIA · WASHINGTON UNIVERSITY · PI HOLLOSZY, JOHN O. · 2001 to 2009
$8.9M
Dietary Energy Restriction and Metabolic Aging in HumansU01AG020480 · NIA · TUFTS UNIVERSITY BOSTON · PI ROBERTS, SUSAN B · 2002 to 2008
$8.2M
NCATS NIH HHS UL1 TR001855NCI NIH HHS DP2 CA195765NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA129769NCI NIH HHS R01 CA172119NCI NIH HHS R01 CA218496NCI NIH HHS R01 CA231014NCI NIH HHS R21 CA218732NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NCI NIH HHS UG1 CA189961NIA NIH HHS K24 AG056589NIA NIH HHS P01 AG043376NIA NIH HHS P01 AG062413NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG052964NIA NIH HHS R21 AG053198NIA NIH HHS R21 AG059206NIA NIH HHS R33 AG059206NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIA NIH HHS U01 AG020478NIA NIH HHS U01 AG020480NIA NIH HHS U01 AG020487NIA NIH HHS U01 AG057545NIA NIH HHS U19 AG056278
6 · The paper itself

Abstract

Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from cancer and its treatment. Thus, survivors often show an accelerated development of multiple geriatric syndromes and need therapeutic interventions. To advance progress in this area, the National Cancer Institute convened the second of 2 think tanks under the auspices of the Cancer and Accelerated Aging: Advancing Research for Healthy Survivors initiative. Experts assembled to share evidence of promising strategies to prevent, slow, or reverse the aging consequences of cancer and its treatment. The meeting identified research and resource needs, including geroscience-guided clinical trials; comprehensive assessments of functional, cognitive, and psychosocial vulnerabilities to assess and predict age-related outcomes; preclinical and clinical research to determine the optimal dosing for behavioral (eg, diet, exercise) and pharmacologic (eg, senolytic) therapies; health-care delivery research to evaluate the efficacy of integrated cancer care delivery models; optimization of intervention implementation, delivery, and uptake; and patient and provider education on cancer and treatment-related late and long-term adverse effects. Addressing these needs will expand knowledge of aging-related consequences of cancer and cancer treatment and inform strategies to promote healthy aging of cancer survivors.

Indexed as

AgingCancer SurvivorsCognitive DysfunctionFrailtyHumansMultiple Chronic ConditionsNational Cancer Institute (U.S.)NeoplasmsUnited States

Identifiers

PMID32348501
PMCPMC7850536
OpenAlexW3019108148

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.