Evidence map›Paper›PMID 32350385›Full record

Trial reportScientific reports2020

Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis.

Nicholas J Andreas, Robindra Basu Roy, Maria Gomez-Romero, Verena Horneffer-van der Sluis, Matthew R Lewis, Stephane S M Camuzeaux, Beatriz Jiménez, Joram M Posma, Leopold Tientcheu, Uzochukwu Egere and 4 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Pediatric Tuberculosis Diagnostics: Present and Future.Journal of the Pediatric Infectious Diseases Society · 2022
    Article
  8. Review
  9. Article
  10. Host lipidome and tuberculosis treatment failure.The European respiratory journal · 2022
    Article
  11. Observational
  12. Pediatric Tuberculosis: The Impact of "Omics" on Diagnostics Development.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Nicholas J Andreas *Centre for International Child Health, Department of Paediatrics, Imperial College London, St. Mary's Hospital, Praed Street, London, W2 1NY, United Kingdom.ORCID http://orcid.org/0000-0002-7224-0420
Robindra Basu Roy *Centre for International Child Health, Department of Paediatrics, Imperial College London, St. Mary's Hospital, Praed Street, London, W2 1NY, United Kingdom.
Maria Gomez-RomeroDivision of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom.
Verena Horneffer-van der SluisDivision of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom.
Matthew R LewisDivision of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom.
Stephane S M CamuzeauxMRC-NIHR National Phenome Centre, Department of Surgery and Cancer, Imperial College London, IRDB Building, Du Cane Road, London, W12 0NN, United Kingdom.ORCID http://orcid.org/0000-0002-4614-4662
Beatriz JiménezDivision of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom.
Joram M PosmaDivision of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom.
Leopold TientcheuMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Vaccines and Immunity Theme, Atlantic Road, Fajara, The Gambia.ORCID http://orcid.org/0000-0002-2189-3501
Uzochukwu EgereMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Vaccines and Immunity Theme, Atlantic Road, Fajara, The Gambia.
Abdou SillahMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Vaccines and Immunity Theme, Atlantic Road, Fajara, The Gambia.ORCID http://orcid.org/0000-0001-8332-2475
Toyin TogunMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Vaccines and Immunity Theme, Atlantic Road, Fajara, The Gambia.
Elaine HolmesDivision of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom.
Beate KampmannCentre for International Child Health, Department of Paediatrics, Imperial College London, St. Mary's Hospital, Praed Street, London, W2 1NY, United Kingdom. beate.kampmann@lshtm.ac.uk.ORCID http://orcid.org/0000-0002-6546-4709
Imperial College London · GBMRC Unit the Gambia · GMUniversity of London · GBLondon School of Hygiene & Tropical Medicine · GBSt Mary's Hospital · GB

Funding

Medical Research Council MC_EX_MR/K011944/1Medical Research Council MC_EX_MR/P024270/1Medical Research Council MC_PC_12025Medical Research Council MC_UP_A900_1122Medical Research Council MC_UU_00026/2RCUK | Medical Research Council (MRC) MC-PC-12025RCUK | Medical Research Council (MRC) MC_UP_A900/1122RCUK | Medical Research Council (MRC) MR/K007602/1RCUK | Medical Research Council (MRC) MR/K011944/1RCUK | Medical Research Council (MRC) MR/K023446/1RCUK | Medical Research Council (MRC) SRF-2009-02-07
6 · The paper itself

Abstract

We applied a metabonomic strategy to identify host biomarkers in serum to diagnose paediatric tuberculosis (TB) disease. 112 symptomatic children with presumptive TB were recruited in The Gambia and classified as bacteriologically-confirmed TB, clinically diagnosed TB, or other diseases. Sera were analysed using

Indexed as

MetabolomeNuclear Magnetic Resonance, BiomolecularAdolescentChildChild, PreschoolFemaleHumansInfantMaleProspective StudiesTuberculosis, Pulmonary

Identifiers

PMID32350385
PMCPMC7190829
OpenAlexW3021629922

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.