ArticleDiabetologia2020
The pore-forming subunit MCU of the mitochondrial Ca
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Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Impact ofJournal of cardiovascular development and disease · 2026Review
- Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.Molecular metabolism · 2025Article
- Review
- Liver knockout of MCU leads to greater dysregulation of lipid metabolism in MAFLD.Scientific reports · 2024Article
- Review
- TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet.Cell reports · 2024Article
- Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes.Frontiers in molecular biosciences · 2024Review
- Insulin C-peptide secretion on-a-chip to measure the dynamics of secretion and metabolism from individual islets.Cell reports methods · 2023Article
- A Defect in Mitochondrial Complex III but Not in Complexes I or IV Causes Early β-Cell Dysfunction and Hyperglycemia in Mice.Diabetes · 2023Article
- The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases.Biomolecules · 2023Review
- Regulation of Smooth Muscle Cell Proliferation by Mitochondrial Ca2+ in Type 2 Diabetes.International journal of molecular sciences · 2023Article
- CaBiomedicines · 2023Review
- Article
- The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury.Nature communications · 2022Article
- Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.Diabetes · 2022Article
- CaCells · 2022Review
- Contribution of Mitochondria to Insulin Secretion by Various Secretagogues.Antioxidants & redox signaling · 2022Review
- 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells.JCI insight · 2022Article
- Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.Molecular metabolism · 2021Article
- Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 3 countries.
Eleni GeorgiadouSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Elizabeth HaythorneSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Livia Lopez-NoriegaSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Timothy J PullenSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Gabriela da Silva XavierSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Samuel P X DavisPhotonics Group, Department of Physics, Imperial College London, London, UK.
Aida Martinez-SanchezSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Francesca SempliciSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Rosario RizzutoDepartment of Biomedical Sciences, University of Padova, Padua, Italy.
James A McGintyPhotonics Group, Department of Physics, Imperial College London, London, UK.
Paul M FrenchPhotonics Group, Department of Physics, Imperial College London, London, UK.
Matthew C CaneSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Isabelle LeclercSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, Du Cane Road, London, W12 0NN, UK. g.rutter@imperial.ac.uk.ORCID 0000-0001-6360-0343
Imperial College London · GBVanderbilt University · USUniversity of Padua · IT
Funding
TRANSLOCATION OF p66Shc: KINETICS, FUNCTION, APOPTOSISP01AG025532 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIM, KYOUNGMI · 2007 to 2017
$12.1MIntegrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9MTwo-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3MDesigning selective TALK-1 inhibitors to reduce beta-cell dysfunction in diabetesR01DK115620 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2018 to 2021
$1.6MDiabetes UK BDA16/0005485Medical Research Council MR/J0003042/1Medical Research Council MR/K001981/1Medical Research Council MR/K011561/1Medical Research Council MR/K023667/1Medical Research Council MR/L020149/1Medical Research Council MR/L02036X/1Medical Research Council MR/M012646/1Medical Research Council MR/N00275X/1Medical Research Council MR/N020472/1Medical Research Council MR/R010676/1Medical Research Council MR/R022259/1Medical Research Council MR/T002107/1NIA NIH HHS P01 AG025532NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK115620NIDDK NIH HHS T32 DK101003NIH HHS 1 P01 AG025532NIH HHS 1P01AG025532-01A1Wellcome TrustWellcome Trust 212625/Z/18/ZWellcome Trust WT098424AIA
Abstract
aims/hypothesisMitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca
methodsHere, we inactivated the pore-forming subunit of the MCU, encoded by Mcu, selectively in mouse beta cells using Ins1
resultsGlucose-stimulated mitochondrial Ca CONCLUSIONS/
interpretationMCU is crucial for mitochondrial Ca
Indexed as
AnimalsBlotting, WesternCalciumElectrophoresis, Polyacrylamide GelGlucoseInsulin SecretionMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaCalciumGlucoseCalciumGlucose homeostasisInsulin secretionMitochondriaMitochondrial Ca2+ uniporter (MCU)Pancreatic beta cellsType 2 diabetes
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.