Evidence map›Paper›PMID 32353428›Full record

ArticleExperimental eye research2020

AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal.

Monica Akula, Aftab Taiyab, Paula Deschamps, Shannin Yee, Alexander K Ball, Trevor Williams, Judith A West-Mays

Open access · greenAbstract read
In one paragraph

Article in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Studies of mice with a large deletion of the ARPKD-associatedbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Monica AkulaMcMaster University, Health Sciences Centre, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada.
Aftab TaiyabMcMaster University, Health Sciences Centre, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada.
Paula DeschampsMcMaster University, Health Sciences Centre, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada.
Shannin YeeMcMaster University, Health Sciences Centre, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada.
Alexander K BallMcMaster University, Health Sciences Centre, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada.
Trevor WilliamsUniversity of Colorado, Craniofacial Biology, Mail Stop 8120, RC1-S, Rm L18 111, 12801 E. 17th Ave, Aurora, CO, 80045, USA.
Judith A West-MaysMcMaster University, Health Sciences Centre, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada. Electronic address: westmayj@mcmaster.ca.
Health Sciences Centre · CAMcMaster University Medical Centre · CA

Funding

Role of AP-2beta in Anterior Segment DevelopmentR01EY025789 · NEI · MCMASTER UNIVERSITY · PI WEST-MAYS, JUDITH A, WILLIAMS, TREVOR J · 2015 to 2023
$2.8M
NEI NIH HHS R01 EY025789
6 · The paper itself

Abstract

Previously, we have shown that Tfap2b, the gene encoding transcription factor AP-2β, is needed for normal mouse eye development. Specifically, targeted loss of Tfap2b in neural crest cells (NCCs)

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCells, CulturedImmunohistochemistryIntraocular PressureMiceMice, KnockoutModels, AnimalRNATrabecular MeshworkTranscription Factor AP-2RNATranscription Factor AP-2DevelopmentKnockout mouseNeural crestPeriocular mesenchymeReporter mouseSchlemm's canalTrabecular meshwork

Identifiers

PMID32353428
PMCPMC8005257
OpenAlexW3017791378

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.