Evidence map›Paper›PMID 32372265›Full record

SynthesisEuropean journal of nutrition2020

Therapy with probiotics and synbiotics for polycystic ovarian syndrome: a systematic review and meta-analysis.

Mauro Cozzolino, Amerigo Vitagliano, Livia Pellegrini, Martina Chiurazzi, Alessandra Andriasani, Guido Ambrosini, Nicolas Garrido

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 7 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mauro CozzolinoIVIRMA, IVI Foundation, Valencia, Spain. mauro.cozzolino@ivirma.com.
Amerigo VitaglianoUnit of Gynaecology and Obstetrics, Department of Women and Children's Health, University of Padua, Padua, Italy.
Livia PellegriniIVIRMA, IVI Foundation, Valencia, Spain.
Martina ChiurazziDepartment of Clinical Medicine and Surgery, "Federico II", Medical School University, Naples, Italy.
Alessandra AndriasaniUnit of Gynaecology and Obstetrics, Department of Women and Children's Health, University of Padua, Padua, Italy.
Guido AmbrosiniUnit of Gynaecology and Obstetrics, Department of Women and Children's Health, University of Padua, Padua, Italy.
Nicolas GarridoIVIRMA, IVI Foundation, Valencia, Spain.
University of Padua · ITValencian Infertility Institute · ESFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSeveral randomized controlled trials (RCTs) have investigated the use of probiotic/synbiotic in PCOS patients, without clarifying the real use in clinical practice. The aim of this meta-analysis was to evaluate the effectiveness of probiotics and synbiotics on metabolic, hormonal and inflammatory parameters of PCOS.

methodsElectronic databases (MEDLINE, Scopus, EMBASE, ScienceDirect, The Cochrane Database of Systematic Reviews and ClinicalTrials.gov) were searched from their inception until May 2019. The study protocol was registered in PROSPERO with number CRD42018111534. Randomized controlled trials (RCTs) of PCOS's women undergoing therapy at least 8 weeks with probiotics or synbiotics or without therapy were included. The primary outcomes were changes in anthropometric parameters, glucose/insulin metabolism, lipid profile, sex hormones profile, inflammation markers.

results587 patients were included in nine RCT. The administration of probiotic/synbiotic were associated with a significant improvement in FPG, FBI, HOMA I-R, BMI. It also modified Ferriman-Gallway, serum triglycerides, serum testosterone, hs-CRP, NO, TAC, GSH, and MDA. Subgroup analysis of the type of intervention showed that probiotics were associated with greater testosterone and FPG reduction; synbiotics administration resulted in a more pronounced decrease of the FBI. Subgroup analyses on the duration of therapy showed that, probiotic/synbiotic administration had a significantly greater effect on QUICK-I in the case of women with 12-weeks of therapy than in the 8-weeks therapy group. Nevertheless, we did not observe any significant difference was observed in terms of FBI, HOMA-IR, and FPG.

conclusionsProbiotics and synbiotics seem to either an effect on/influence metabolic, hormonal and inflammatory parameters, or can influence them. Consequently, it could lead to an improvement of fertility in PCOS.

Indexed as

Insulin ResistancePolycystic Ovary SyndromeProbioticsSynbioticsFemaleHumansInsulinInsulinInfertilityPolycystic ovarian syndromeProbioticsSynbioticTestosterone

Identifiers

PMID32372265
OpenAlexW3023269779

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.