Evidence map›Paper›PMID 32380991›Full record

ArticleBMC endocrine disorders2020

Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women.

Maha H Daghestani, Mazin H Daghestani, Mamoon Daghistani, Khushboo Ambreen, Fadwa S Albalawi, Lina M AlNeghery, Arjumand S Warsy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Genetic Variants inGenes · 2024
    Article
  5. Effects ofThe Journal of international medical research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Maha H DaghestaniDepartment of Zoology, Female Center for Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.
Mazin H DaghestaniDepartment of Obstetrics & Gynaecology, Umm-Al-Qura University, Makkah, Saudi Arabia.
Mamoon DaghistaniDepartment of Surgery, King Abdulaziz Medical City, National Guard Heath Affairs, Jeddah, Saudi Arabia.
Khushboo AmbreenDepartment of Biotechnology, Integral University, Lucknow, India.
Fadwa S AlbalawiDepartment of Zoology, Female Center for Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.
Lina M AlNegheryDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Arjumand S WarsyCentral Laboratory, Female Center for Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia. aswarsy@gmail.com.ORCID http://orcid.org/0000-0001-6957-203X
Umm al-Qura University · SAImam Mohammad ibn Saud Islamic University · SAIntegral University · INKing Abdulaziz Medical City · SAKing Saud Medical City · SAKing Saud University · SA

Funding

Research Center, Female Center for Scientific and Medical Colleges, King Saud University (SA) 11
6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is a complex multifactorial disorder, affecting millions of women worldwide. The role of genetic polymorphisms of the KISS1 gene on the development of PCOS is still obscure. This study was designed to investigate the probable influence of KISS1 gene polymorphisms on PCOS and its associated variables: BMI, waist-hip ratio, kisspeptin, LH, FSH, and LH-FSH ratio.

methodsThe study comprised 104 PCOS women and 109 controls, with age ranging from 19 to 36 years. BMI, waist-hip ratio, and circulating levels of kisspeptin, LH, and FSH were measured. DNA was extracted, and genotyping of the KISS1 gene was carried out by nucleotide sequencing. The PCOS-associated variables were analyzed in different genotypes of single nucleotide polymorphisms (SNPs) of the KISS1 gene.

resultsThe values of waist-hip ratio (WHR), LH, and LH-FSH ratio were significantly higher in PCOS women than controls. BMI, kisspeptin, and FSH levels exhibited no significant difference between the groups. Six novel SNPs of KISS1 gene were identified. Three: rs372790354G > A, rs12998G > A, and rs35431622A > T were investigated. Among these SNPs, the genotype and allele frequencies of rs372790354 showed significant association with PCOS (GA: p = 0.018, AA: p = 0.022, mutant allele-A: p = 0.021) and the G allele was protective. The values of LH, kisspeptin, and WHR of PCOS women were significantly influenced (p < 0.05) by the AA genotype of rs372790354. The other two SNPs rs12998G > A and rs35431622A > T revealed no significant influence on PCOS and associated variables. Haplotypes were constructed, but there was no significant difference between the patients and controls.

conclusionIn conclusion, this is the first study, which reports a significant influence of KISS1 gene polymorphism (rs372790354G > A) on PCOS and its associated variables. However, more extensive research is necessary to confirm these findings.

Indexed as

AdultBody Mass IndexFemaleFollicle Stimulating HormoneGenotypeHumansKisspeptinsLuteinizing HormonePhenotypePolycystic Ovary SyndromePolymorphism, Single NucleotideSaudi ArabiaWaist-Hip RatioYoung AdultFollicle Stimulating HormoneKISS1 protein, humanKisspeptinsLuteinizing HormoneFSHKISS1 gene polymorphismsKisspeptinLHPolycystic ovary syndromeWaist-hip ratio

Identifiers

PMID32380991
PMCPMC7203813
OpenAlexW3022729255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.