Evidence map›Paper›PMID 32382447›Full record

ArticleJournal of advanced research2020

Major flavonoids from

Hossam M Abdallah, Noura A Hassan, Ali M El-Halawany, Gamal A Mohamed, Martin K Safo, Hany M El-Bassossy

Open access · goldAbstract read
In one paragraph

Article in Journal of advanced research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Vasodilator activity ofToxicon: X · 2023
    Article
  4. Vasorelaxant Effects ofPharmaceuticals (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Hossam M AbdallahDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Noura A HassanDepartment of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Ali M El-HalawanyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Gamal A MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Martin K SafoDepartment of Medicinal Chemistry, Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, VA 23219, USA.
Hany M El-BassossyDepartment of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Cairo University · EGZagazig University · EGAl-Azhar University · EGVirginia Commonwealth University · US

Funding

Hemoglobin Modifiers for Sickle Cell Disease TherapyR01MD009124 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAFO, MARTIN K · 2014 to 2018
$2.1M
NIMHD NIH HHS R01 MD009124
6 · The paper itself

Abstract

Vasodilators are important pharmacologic agents for managing and/or treating hypertension. Medicinal plants are considered as valuable source of bioactive compounds. We used a bioguided approach to isolate, identify, and investigate the possible vasodilation activities and mechanism(s) of the prepared methanol extract from aerial parts of

Indexed as

AC, adenylate cyclaseCa2+, calciumCaM, calmodulinCaMKII, Ca2+/calmodulin-dependent protein kinase IIcGMP, cyclic guanosine monophosphateEndothelial nitric oxideeNOS, endothelial nitric oxide synthaseFlavonoidsGTP, guanosine triphosphateHypertensionL-NAME, Nω-nitro-L-arginine methyl esterMAPP, methanol extract from aerial parts of Psiadia punctulataMDL, cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine.HCl (MDL-12, 330A)NO, nitric oxideNOS, nitric oxide synthaseODQ, 1H-(1,2,4)-oxadiazolo(4,3-a)quinoxalin-1-onePE, phenylephrinePI3K, phosphoinositide 3-kinasePKG, protein kinase GPP, Psiadia punctulataPsiadia punctulataTEA, tetraethylammonium chlorideVasodilatorVSMCs, vascular smooth muscle cells

Identifiers

PMID32382447
PMCPMC7200196
OpenAlexW2996953900

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.