SynthesisNeuropsychology review2020
Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis.
Synthesis in Neuropsychology review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Executive functioning in adolescents with internalizing disorders: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.Psychological medicine · 2025Pooled it
- Taste dysfunction as a predictor of depression in schizophrenia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Depression and episodic memory across the adult lifespan: A meta-analytic review.Psychological bulletin · 2021Pooled it
- Neurocognitive function as outcome and predictor for prefrontal transcranial direct current stimulation in major depressive disorder: an analysis from the DepressionDC trial.European archives of psychiatry and clinical neuroscience · 2025Trial
- Effectiveness of cognitive remediation in subjects with major depressive disorder: A multicenter randomized controlled study in a real-world setting.European psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Depression and cognition: is there a bidirectional relationship?Aging & mental health · 2026Article
- Comparison of Cognitive Functions in Patients with Autogenous and Reactive Obsessive-Compulsive Disorder.Brain sciences · 2026Article
- The impact of mental health symptoms on relational memory performance.Cognitive, affective & behavioral neuroscience · 2026Article
- Social network structure and depression by gender in rural Honduras: a cross-sectional study.BMJ open · 2026Observational
- Article
- Brain network centrality following stress in adults with major depressive disorder and childhood trauma.Neurobiology of stress · 2026Article
- Longevity.Clinical medicine & research · 2026Review
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
- Exploratory characterization of gut microbiota and cognitive profiles in adolescents with subthreshold depression: a shotgun metagenomics sequencing study.Npj mental health research · 2026Article
- Latent profiles and network analysis of adolescent depression and cognitive impairment.BMC psychiatry · 2026Article
- Shared and distinct alterations in brain connectivity and cognitive function in subthreshold and major depression.Psychological medicine · 2026Article
- Virtual reality-based cognitive remediation in severe mental illness: Current evidence from a narrative review.Schizophrenia research. Cognition · 2026Review
- Identification of genetic associations and key influences contributing to the pathway from social isolation or loneliness to depression.European archives of psychiatry and clinical neuroscience · 2026Article
- Executive Dysfunction and Depression Risk in Adolescence: Functional-MRI Analysis of Transient Network States During a Working Memory Task.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Depression has been shown to negatively impact neurocognitive functions, particularly those governed by fronto-subcortical networks, such as executive functions. Converging evidence suggests that depression-related executive dysfunction is greater at older ages, however, this has not been previously confirmed by meta-analysis. We performed a systematic review and meta-analysis, using three-level models, on peer-reviewed studies that examined depression-related differences in cognitive control in healthy community-dwelling individuals of any age. We focused on studies of cognitive control as defined by the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which centers on goal-directed behavior, such as goal selection (updating, representations, maintenance), response selection (inhibition or suppression), and performance monitoring. In 16,806 participants aged 7 to 97 across 76 studies, both clinical depression and subthreshold depressive symptoms were associated with cognitive control deficits (Hedges' g = -0.31). This relationship was stronger in study samples with an older mean age. Within studies with a mean age of 39 years or higher, which represents the median age in our analyses, the relationship was stronger in clinical compared to subthreshold depression and in individuals taking antidepressant medication. These findings highlight the importance of clinicians screening for cognitive control dysfunction in patients with depression, particularly in later stages of adulthood.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.