Evidence map›Paper›PMID 32391791›Full record

ArticleeLife2020

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.

Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

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  10. Research progress on the mechanism of exosome-mediated virus infection.Frontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Benjamin G ButtDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-6718-0470
Danielle J OwenDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Cy M JeffriesEuropean Molecular Biology Laboratory (EMBL) Hamburg Site, Hamburg, Germany.
Lyudmila IvanovaDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Chris H HillDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-7037-0611
Jack W HoughtonCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Md Firoz AhmedDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Robin AntrobusCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Dmitri I SvergunEuropean Molecular Biology Laboratory (EMBL) Hamburg Site, Hamburg, Germany.
John J WelchDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Colin M CrumpDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9918-9998
Stephen C GrahamDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-4547-4034
University of Cambridge · GBEuropean Molecular Biology Laboratory · DE

Funding

Wellcome 098406/Z/12/BWellcome Trust
6 · The paper itself

Abstract

Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear. Herpes simplex virus (HSV)-1 proteins pUL7 and pUL51 form a complex required for efficient virus envelopment. We show that interaction between homologues of pUL7 and pUL51 is conserved across human herpesviruses, as is their association with

Indexed as

Virus AssemblyHEK293 CellsHeLa CellsHerpes SimplexHerpesvirus 1, HumanHumansModels, MolecularPhosphoproteinsProtein BindingProtein Interaction Domains and MotifsProtein Structure, QuaternaryProtein Structure, Tertiarytrans-Golgi NetworkViral Matrix ProteinsViral ProteinsVirus ReplicationPhosphoproteinsUL51 protein, HSV-1UL7 protein, human herpesvirus 1Viral Matrix ProteinsViral Proteinsfocal adhesionshuman cytomegalovirus (hcmv)infectious diseasemicrobiologymolecular biophysicssecondary envelopmentsmall-angle X-ray scattering (SAXS)structural biologyvirusvirus budding

Identifiers

PMID32391791
PMCPMC7289601
OpenAlexW3020983288

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.