Evidence map›Paper›PMID 32393559›Full record

Trial reportAnnals of family medicine2020

Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial.

Regina Wing Shan Sit, Ricky Wing Keung Wu, David Rabago, Kenneth Dean Reeves, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung, Samuel Yeung Shan Wong

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of family medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05966948 (Hypertonic Dextrose Prolotherapy Versus Normal Saline Intra-articular Injection Among Knee Osteoarthritis With Obese Patient), which is not on this map. Cited by 32 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05966948 nacompletednot on this mapstarted 2023, after this paper: background citation

Hypertonic Dextrose Prolotherapy Versus Normal Saline Intra-articular Injection Among Knee Osteoarthritis With Obese Patient

TypeinterventionalSponsorRumah Sakit Umum Daerah Haji Provinsi Jawa Timur, IndonesiaRan2023 to 2023Enrolled40ConditionsKnee Osteoarthritis, ObesityArmsDextrose Solution, Normal Saline
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Trial
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  11. Review
  12. Article
  13. Cartilage · 2026
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  19. Advanced Non-Operative Interventions for Anterior Knee Pain.Current reviews in musculoskeletal medicine · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Regina Wing Shan SitJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong reginasit@cuhk.edu.hk.
Ricky Wing Keung WuJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
David RabagoDepartment of Family Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Kenneth Dean ReevesDepartment of Physical Medicine and Rehabilitation, The University of Kansas Medical Center, Kansas City, Kansas.
Dicken Cheong Chun ChanJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Benjamin Hon Kei YipJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Vincent Chi Ho ChungJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Samuel Yeung Shan WongJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo test the efficacy of intra-articular hypertonic dextrose prolotherapy (DPT) vs normal saline (NS) injection for knee osteoarthritis (KOA).

methodsA single-center, parallel-group, blinded, randomized controlled trial was conducted at a university primary care clinic in Hong Kong. Patients with KOA (n = 76) were randomly allocated (1:1) to DPT or NS groups for injections at weeks 0, 4, 8, and 16. The primary outcome was the Western Ontario McMaster University Osteoarthritis Index (WOMAC; 0-100 points) pain score. The secondary outcomes were the WOMAC composite, function and stiffness scores; objectively assessed physical function test results; visual analogue scale (VAS) for knee pain; and EuroQol-5D score. All outcomes were evaluated at baseline and at 16, 26, and 52 weeks using linear mixed model.

resultsRandomization produced similar groups. The WOMAC pain score at 52 weeks showed a difference-in-difference estimate of -10.34 (95% CI, -19.20 to -1.49,

conclusionIntra-articular dextrose prolotherapy injections reduced pain, improved function and quality of life in patients with KOA compared with blinded saline injections. The procedure is straightforward and safe; the adherence and satisfaction were high.

Indexed as

AgedCluster AnalysisFemaleGlucose Solution, HypertonicHumansInjections, Intra-ArticularMaleMiddle AgedOsteoarthritis, KneePain MeasurementProlotherapySingle-Blind MethodTreatment OutcomeGlucose Solution, Hypertonicintra-articular hypertonic dextroseknee osteoarthritisnormal salineprolotherapyrandomized clinical trial

Identifiers

PMID32393559
PMCPMC7214004

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.