Evidence map›Paper›PMID 32393613›Full record

ArticleBMJ open2020

Biomarkers of exposure and early effect in three contaminated sites of southern Italy: protocols for etiological epidemiological studies.

Francesca Gorini, Elisa Bustaffa, Davide Bolignano, Liliana Cori, Francesco Faita, Amalia Gastaldelli, Monica Interdonato, Fabizio Minichilli, Giancarlo Quattrone, Francesco Squadrito and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Francesca GoriniNational Research Council, Institute of Clinical Physiology, Pisa, Italy fgorini@ifc.cnr.it.ORCID 0000-0002-4619-6227
Elisa BustaffaNational Research Council, Institute of Clinical Physiology, Pisa, Italy.
Davide BolignanoNational Research Council, Institute of Clinical Physiology, Reggio Calabria, Italy.
Liliana CoriNational Research Council, Institute of Clinical Physiology, Pisa, Italy.
Francesco FaitaNational Research Council, Institute of Clinical Physiology, Pisa, Italy.
Amalia GastaldelliNational Research Council, Institute of Clinical Physiology, Pisa, Italy.
Monica InterdonatoDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Messina, Italy.
Fabizio MinichilliNational Research Council, Institute of Clinical Physiology, Pisa, Italy.
Giancarlo QuattroneLocal Health Authority of Messina, Messina, Italy.
Francesco SquadritoDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Messina, Italy.
Giovanni TripepiNational Research Council, Institute of Clinical Physiology, Reggio Calabria, Italy.
Cristina VassalleFondazione CNR-Regione Toscana G Monasterio, Laboratory Medicine Unit, Pisa, Italy.
Fabrizio BianchiNational Research Council, Institute of Clinical Physiology, Pisa, Italy.
Istituto di Fisiologia Clinica · ITUniversity of Messina · ITFondazione Toscana Gabriele Monasterio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEnvironmental pollution has been progressively becoming one of the main risk factors to human diseases. In particular, populations living in high-contaminated sites are particularly exposed to environmental toxicants, with consequent increased risks to human health. In Italy, there are currently ongoing three epidemiological etiological studies aimed at evaluating the association between exposure to inorganic and organic chemicals and presence of biological markers of early effects in population living in three National Priority Contaminated Sites (NPCSs). Specifically, the correlations concern preclinical indicators of liver disease in Priolo NPCS, thyroid diseases in Milazzo-Valle del Mela NPCS and cardiovascular risk and kidney damage in Crotone NPCS. METHODS AND ANALYSIS: Overall, approximately 1300 subjects of both sexes will be enrolled in the three NPCSs according to specific inclusion criteria. For each subject, serum and urine specimens are collected, on which the determination of biological markers of exposure and early effects for the selected outcomes are performed. Individual information on environmental and occupational exposure, medical history, diet and life habits is obtained through questionnaires provided by web platform. In Milazzo-Valle del Mela and Crotone NPCSs, not invasive instrumental and imaging examinations are performed in order to evaluate further risk factors of thyroid carcinoma and cardiovascular disease, respectively. ETHICS AND DISSEMINATION: The protocol studies have been approved by the Ethics Committees responsible for the three involved NPCSs: the Ethics Committee 'Catania 2' for the NPCS of Priolo (21 July 2017, n. 500/2017/CECT2), the Ethics Committee of the University Hospitals of Messina for the NPCS of Milazzo-Valle del Mela (19 February 2018, n.2/2018); the Ethics Committee of the Region of Calabria for the NPCS of Crotone (20 July 2017, n. 174). Results will be disseminated among policy-makers, citizens, stakeholders and scientific community through the organisation of conferences and events, and the publication on international peer/reviewed journals.

Indexed as

Environmental ExposureEnvironmental PollutionBiomarkersEpidemiologic StudiesFemaleHumansItalyMaleBiomarkersepidemiologyhealth policyprotocols & guidelinespublic health

Identifiers

PMID32393613
PMCPMC7223157
OpenAlexW3021794950

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.