Evidence map›Paper›PMID 32397091›Full record

SynthesisNutrients2020

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies.

Salvatore Benvenga, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Armando Patrizio, Sabrina Rosaria Paparo, Stefania Camastra, Daniela Bonofiglio, Alessandro Antonelli, Poupak Fallahi

Abstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Nutritional Management of Thyroiditis of Hashimoto.International journal of molecular sciences · 2022
    Review
  8. Myoinositol in Autoimmune Thyroiditis.Frontiers in endocrinology · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. L-T4 Therapy in Enteric Malabsorptive Disorders.Frontiers in endocrinology · 2021
    Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Salvatore BenvengaMaster Program on Childhood, Adolescent and Women's Endocrine Health, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina.
Silvia Martina FerrariDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Giusy EliaDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Francesca RagusaDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Armando PatrizioDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Sabrina Rosaria PaparoDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Stefania CamastraDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Daniela BonofiglioDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.ORCID 0000-0002-4142-0496
Alessandro AntonelliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5211-6342
Poupak FallahiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nutraceuticals are defined as a food, or parts of a food, that provide medical or health benefits, including the prevention of different pathological conditions, and thyroid diseases, or the treatment of them. Nutraceuticals have a place in complementary medicines, being positioned in an area among food, food supplements, and pharmaceuticals. The market of certain nutraceuticals such as thyroid supplements has been growing in the last years. In addition, iodine is a fundamental micronutrient for thyroid function, but also other dietary components can have a key role in clinical thyroidology. Here, we have summarized the in vitro, and in vivo animal studies present in literature, focusing on the commonest nutraceuticals generally encountered in the clinical practice (such as carnitine, flavonoids, melatonin, omega-3, resveratrol, selenium, vitamins, zinc, and inositol), highlighting conflicting results. These experimental studies are expected to improve clinicians' knowledge about the main supplements being used, in order to clarify the potential risks or side effects and support patients in their use.

Indexed as

Dietary SupplementsHomeostasisAnimalsCarnitineFatty Acids, Omega-3FlavonoidsHumansInositolIodineMelatoninResveratrolSeleniumThyroid DiseasesThyroid GlandVitaminsZincCarnitineFatty Acids, Omega-3FlavonoidsInositolIodineMelatoninResveratrolSeleniumVitaminsZinccarnitineflavonoidsmelatoninnutraceuticalsomega-3resveratrolseleniumthyroidvitaminszinc

Identifiers

PMID32397091
PMCPMC7285044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.