Evidence map›Paper›PMID 32398094›Full record

ReviewRetrovirology2020

Functional properties and sequence variation of HTLV-1 p13.

Maria Omsland, Micol Silic-Benussi, Ramona Moles, Sarkis Sarkis, Damian F J Purcell, David Yurick, Georges Khoury, Donna M D'Agostino, Vincenzo Ciminale, Genoveffa Franchini

Open access · goldAbstract readReview
In one paragraph

Review in Retrovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. How Can We Prevent Mother-to-Child Transmission of HTLV-1?International journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Maria OmslandAnimal Models and Retroviral Vaccines Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Micol Silic-BenussiVeneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Ramona MolesAnimal Models and Retroviral Vaccines Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sarkis SarkisAnimal Models and Retroviral Vaccines Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Damian F J PurcellDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
David YurickDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Georges KhouryDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Donna M D'AgostinoDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Vincenzo CiminaleVeneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. franchig@mail.nih.gov.
Peter Doherty Institute · AUNational Cancer Institute · USNational Institutes of Health · USUniversity of Padua · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

T-cell Transformation by OncovirusesZIABC005645 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FRANCHINI, GENOVEFFA · 2009 to 2025
$14.1M
Italian Association for Cancer Research 17794National Health and Medical Research Council of Australia APP1052979National Health and Medical Research Council of Australia APP1129320
6 · The paper itself

Abstract

Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia and other diseases associated with HTLV-1 infection remain to be fully understood. This review describes the functional properties of p13, an 87-amino acid protein coded by HTLV-1 open reading frame II (orf-II). p13 is mainly localized in the inner membrane of the mitochondria, where it induces potassium (K

Indexed as

Genetic VariationAnimalsHumansHuman T-lymphotropic virus 1Open Reading FramesRetroviridae ProteinsRetroviridae Proteinsrof protein, Human T-lymphotropic virus 1Cell deathHTLV-1HTLV-1CHuman T cell leukemia virus type-1Mitochondriap13

Identifiers

PMID32398094
PMCPMC7218495
OpenAlexW3028456448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.