Evidence map›Paper›PMID 32408242›Full record

ArticleBlood cells, molecules & diseases2020

The IL-33 Receptor/ST2 acts as a positive regulator of functional mouse bone marrow hematopoietic stem and progenitor cells.

Maegan L Capitano, Brad Griesenauer, Bin Guo, Scott Cooper, Sophie Paczesny, Hal E Broxmeyer

Open access · hybridAbstract read
In one paragraph

Article in Blood cells, molecules & diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Discovery of highly immunogenic spleen-resident FCGR3Cellular & molecular immunology · 2023
    Article
  4. IL-33 induces histidine decarboxylase, especially in c-kitInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maegan L CapitanoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States of America. Electronic address: malcapit@iupui.edu.
Brad GriesenauerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States of America; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Bin GuoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Scott CooperDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Sophie PaczesnyDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States of America; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Hal E BroxmeyerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States of America. Electronic address: hbroxmey@iupui.edu.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · US

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Dual targeting of tumoral microenvironment and tumoral cells by blocking the IL-33/ST2 pathwayU01CA232491 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHEUNG, NAI-KONG V, PACZESNY, SOPHIE · 2018 to 2020
$4.3M
Controlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and DiseaseR35HL139599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E. · 2018 to 2021
$3.1M
Translating Novel Drug-Targetable Biomarkers to Treat Graft versus Host DiseaseR01CA168814 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PACZESNY, SOPHIE · 2013 to 2024
$3.0M
DEK Regulation of Hematopoietic Stem Cell Renewal, Fate, and HematopoiesisR01DK109188 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., MARKOVITZ, DAVID MICHAEL · 2016 to 2019
$2.0M
NCI NIH HHS R01 CA168814NCI NIH HHS U01 CA232491NHLBI NIH HHS R35 HL139599NIDDK NIH HHS R01 DK109188NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

There is a paucity of information on a potential role for the IL-33 receptor/ST2 in the regulation of mouse bone marrow (BM) hematopoietic stem (HSC) and progenitor (HPC) cells. Comparing the BM of st2

Indexed as

AnimalsCells, CulturedGene DeletionGene ExpressionHematopoiesisHematopoietic Stem CellsInterleukin-1 Receptor-Like 1 ProteinMiceMice, Inbred C57BLIl1rl1 protein, mouseInterleukin-1 Receptor-Like 1 ProteinCytokineCytokine receptorHematopoiesisHematopoietic progenitor cellsHematopoietic stem cellsST2

Identifiers

PMID32408242
PMCPMC7788514
OpenAlexW3022753568

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.