Evidence map›Paper›PMID 32409569›Full record

ArticleJournal of cell science2020

Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy.

Shanshan Qin, Dan N Predescu, Monal Patel, Patrick Drazkowski, Balaji Ganesh, Sanda A Predescu

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Roles of LncRNAs in the Pathogenesis of Pulmonary Hypertension.Reviews in cardiovascular medicine · 2024
    Review
  11. Article
  12. Long noncoding RNAGenes & diseases · 2022
    Review
  13. Sex differences and altered mitophagy in experimental pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Genetic Delivery and Gene Therapy in Pulmonary Hypertension.International journal of molecular sciences · 2021
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shanshan QinDepartment of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Dan N PredescuDepartment of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Monal PatelDivision of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Patrick DrazkowskiDepartment of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Balaji GaneshDivision of Bioanalytics, Biophysics and Cytomics, University of Illinois at Chicago, Chicago, IL 60612, USA.
Sanda A PredescuDepartment of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine, Rush University Medical Center, Chicago, IL 60612, USA Sanda_Predescu@rush.edu.ORCID 0000-0002-9386-6756
Rush University Medical Center · USNorthwestern University · USUniversity of Illinois Chicago · US

Funding

Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Nitric Oxide in Pulmonary HypertensionR37HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2009 to 2018
$3.9M
Cleavage of Intersectin-1s by Granzyme B and Pulmonary Arterial HypertensionR01HL127022 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI PREDESCU, SANDA A · 2015 to 2024
$3.1M
NHLBI NIH HHS R01 HL060917NHLBI NIH HHS R01 HL127022NHLBI NIH HHS R24 HL123767NHLBI NIH HHS R37 HL060917
6 · The paper itself

Abstract

The sex-biased disease pulmonary arterial hypertension (PAH) is characterized by the proliferation and overgrowth of dysfunctional pulmonary artery endothelial cells (PAECs). During inflammation associated with PAH, granzyme B cleaves intersectin-1 to produce N-terminal (EH

Indexed as

Hypertension, PulmonaryPulmonary ArteryAnimalsCell ProliferationCells, CulturedEndothelial CellsFemaleHumansMaleMiceSex Characteristicsc-FosELK1Endothelial cellsIntersectinKLF2lncRNA Xistp38 to ERK1/2 activity ratioPlexiform phenotypeProliferationSexual dimorphism

Identifiers

PMID32409569
PMCPMC7240306
OpenAlexW3025150890

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.