Evidence map›Paper›PMID 32410874›Full record

ArticleMediators of inflammation2020

Autophagy Contributes to Host Immunity and Protection against Zika Virus Infection via Type I IFN Signaling.

Yuyi Huang, Yujie Wang, Shuhui Meng, Zhuohang Chen, Haifan Kong, Ting Pan, Gen Lu, Xuefeng Li

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yuyi HuangThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; The Second Affiliated Hospital of Guangzhou Medical University, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology; Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0003-4239-9067
Yujie WangThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; The Second Affiliated Hospital of Guangzhou Medical University, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology; Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0003-1765-1865
Shuhui MengThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; The Second Affiliated Hospital of Guangzhou Medical University, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology; Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Zhuohang ChenSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 510006, China.ORCID https://orcid.org/0000-0002-6866-8942
Haifan KongNan Shan School, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0001-6973-1520
Ting PanSchool of Medicine, Sun Yat-sen University, Guangzhou 510080, China.ORCID https://orcid.org/0000-0002-7106-7312
Gen LuGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-3224-5865
Xuefeng LiThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; The Second Affiliated Hospital of Guangzhou Medical University, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology; Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0001-8146-8374
Second Affiliated Hospital of Guangzhou Medical University · CNGuangzhou Medical University · CNSun Yat-sen University · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have indicated that the Zika virus (ZIKV) has a significant impact on the fetal brain, and autophagy is contributing to host immune response and defense against virus infection. Here, we demonstrate that ZIKV infection triggered increased LC3 punctuation in mouse monocyte-macrophage cell line (RAW264.7), mouse microglial cell line (BV2), and hindbrain tissues, proving the occurrence of autophagy both

Indexed as

AutophagyImmune SystemAnimalsChlorocebus aethiopsMacrophagesMiceMice, Inbred C57BLMonocytesPhagocytesRAW 264.7 CellsRNA, Small InterferingSignal TransductionVero CellsZika VirusZika Virus InfectionRNA, Small Interfering

Identifiers

PMID32410874
PMCPMC7204160
OpenAlexW3021559945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.