Evidence map›Paper›PMID 32415506›Full record

ReviewMolecular biology reports2020

Potential of stem cell therapy in intracerebral hemorrhage.

Abel Po-Hao Huang, Yi-Hua Hsu, Meng-Shiue Wu, Hsin-Han Tsai, Chia-Yi Su, Thai-Yen Ling, Shan-Hui Hsu, Dar-Ming Lai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Recent Stem Cell Research on Hemorrhagic Stroke : An Update.Journal of Korean Neurosurgical Society · 2022
    Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Abel Po-Hao Huang *Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Yi-Hua Hsu *Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Meng-Shiue WuDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsin-Han TsaiDepartment of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Chia-Yi SuDepartment of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Thai-Yen LingDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shan-Hui HsuInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan.
Dar-Ming LaiDepartment of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan. dmlai@ntu.edu.tw.
National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

National Taiwan University Hospital 108C101-92
6 · The paper itself

Abstract

Spontaneous intracerebral hemorrhage (ICH) is a common disease associated with high mortality and morbidity. The treatment of patients with ICH includes medical and surgical interventions. New areas of surgical intervention have been focused on the evacuation of hematoma through minimally invasive neurosurgery. In contrast, there have been no significant advances in the development of medical interventions for functional recovery after ICH. Stem cells exert multiple therapeutic functions and have emerged as a promising treatment strategy. Herein, we summarized the pathophysiology of ICH and its treatment targets, and we introduced the therapeutic mechanisms of stem cells (e.g. neutrotrophy and neuroregeneration). Moreover, we reviewed and summarized the experimental designs of the preclinical studies, including the types of cells and the timing and routes of stem cell administration. We further listed and reviewed the completed/published and ongoing clinical trials supporting the safety and efficacy of stem cell therapy in ICH. The limitations of translating preclinical studies into clinical trials and the objectives of future studies were discussed. In conclusion, current literatures showed that stem cell therapy is a promising treatment in ICH and further translation research on judiciously selected group of patients is warranted before it can be extensively applied in clinical practice.

Indexed as

Cell- and Tissue-Based TherapyCerebral HemorrhageHematomaHumansStem CellsStem Cell TransplantationClinical trialHemorrhagic strokeIntracerebral hemorrhagePreclinical studyStem cell therapyTranslational medicine

Identifiers

PMID32415506
OpenAlexW3025429771

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.