Evidence map›Paper›PMID 32420547›Full record

ArticleRadiology. Cardiothoracic imaging2020

Left Ventricular Extracellular Volume Expansion Is Not Associated with Atrial Fibrillation or Atrial Fibrillation-mediated Left Ventricular Systolic Dysfunction.

Suvai Gunasekaran, Daniel C Lee, Bradley P Knight, Lexiaozi Fan, Jeremy D Collins, Kelvin Chow, James C Carr, Rod Passman, Daniel Kim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Chewing the Fat on Atrial Fibrillation.Radiology. Cardiothoracic imaging · 2020
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Suvai GunasekaranDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).
Daniel C LeeDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).ORCID 0000-0001-9447-4175
Bradley P KnightDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).
Lexiaozi FanDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).ORCID 0000-0002-3714-5372
Jeremy D CollinsDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).ORCID 0000-0003-0707-1736
Kelvin ChowDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).ORCID 0000-0003-0698-1746
James C CarrDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).
Rod PassmanDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).
Daniel KimDepartment of Biomedical Engineering, Northwestern University, Evanston, Ill (S.G., L.F., D.K.); Department of Radiology (S.G., L.F., J.D.C., J.C.C., D.K.) and Division of Cardiology, Internal Medicine (D.C.L., B.P.K., R.P.), Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C.); and Cardiovascular MR R&D, Siemens Healthcare, Chicago, Ill (K.C.).
Northwestern University · US

Funding

Precision MRI of Left Atrial Fibrosis for Patients with Atrial FibrillationR01HL116895 · NHLBI · UNIVERSITY OF UTAH · PI KIM, DANIEL · 2014 to 2025
$5.1M
Wideband 3D LGE and Coronary MRA for Planning Ventricular Tachycardia AblationR01HL151079 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel Kim, Daniel Ching-Hao Lee · 2020 to 2026
$4.0M
Graduate Training Program for Magnetic Resonance ImagingT32EB025766 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Michael Markl · 2019 to 2026
$1.6M
Rapid Real-Time Cardiovascular MRI for Detecting Coronary Artery DiseaseR01HL138578 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DANIEL, LEE, DANIEL CHING-HAO · 2017 to 2019
$1.1M
Rapid Pediatric Cardiovascular MRI without Contrast Agent or AnesthesiaR21EB024315 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DANIEL · 2017 to 2018
$567k
MRI of Left Atrial Hemodynamic Disorders in Atrial FibrillationR21AG055954 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DANIEL, MARKL, MICHAEL · 2017 to 2018
$487k
NHLBI NIH HHS R01 HL116895NHLBI NIH HHS R01 HL138578NHLBI NIH HHS R01 HL151079NIA NIH HHS R21 AG055954NIBIB NIH HHS R21 EB024315NIBIB NIH HHS T32 EB025766
6 · The paper itself

Abstract

purposeTo determine whether left ventricular (LV) extracellular volume (ECV) expansion is associated with atrial fibrillation (AF) or AF-mediated LV systolic dysfunction (LVSD) while minimizing the influence of biologic and imaging methodologic confounders. MATERIALS AND

methodsThis study examined the prevalence of LV ECV expansion in 137 patients with AF (mean age, 62 years ± 11 [standard deviation]; 92 male patients and 45 female patients; 83 paroxysmal and 54 persistent) who underwent preablation cardiovascular MRI. Biologic confounders were minimized by measuring the ECV fraction and excluding patients with severe LV hypertrophy, defined as wall thickness greater than 1.5 cm. Imaging confounders were minimized by using an arrhythmia-insensitive-rapid (AIR) cardiac T1 mapping pulse sequence. Other cardiac functional parameters, including LV ejection fraction (LVEF) and left atrial end-diastolic volume indexed to body surface area, were assessed using cine cardiovascular MRI. A substudy was conducted in 32 patients with no AF (mean age, 54 years ± 16) in sinus rhythm to establish control values and convert these values between the AIR sequence and literature-based modified Look-Locker inversion recovery (MOLLI) values.

resultsThe mean ECV was not significantly different (

conclusionStudy results suggest that an LV ECV expansion is not associated with AF or AF-mediated LVSD.

Identifiers

PMID32420547
PMCPMC7208181
OpenAlexW3018694028

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.