ReviewHuman brain mapping2022
Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.
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In one paragraph
Review in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder.Molecular autism · 2024Pooled it
- Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit/hyperactivity disorder.BMC medicine · 2024Pooled it
- Effects of physical exercise on anxiety depression and emotion regulation in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease.Communications medicine · 2026Article
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder.Molecular psychiatry · 2026Article
- Genetic risk for neurodevelopmental disorders as a potential factor affecting antipsychotic responsiveness in schizophrenia: a postmortem brain study.Frontiers in psychiatry · 2026Article
- Cut from the same cloth: neurobiological continuity between childhood and adult ADHD.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Abnormalities of gray matter volume and structural covariance in children with attention-deficit/hyperactivity disorder subtypes: implications for clinical correlations.European archives of psychiatry and clinical neuroscience · 2025Article
- The overlapping genetic architecture of psychiatric disorders and cortical brain structure.Nature. Mental health · 2025Article
- The distribution of parent-reported autistic and subclinical ADHD traits in children with and without an autism diagnosis.JCPP advances · 2025Article
- Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders.Neuropsychopharmacology reports · 2025Article
- Associations of polygenic risk scores differentiating attention-deficit hyperactivity disorder from autism spectrum disorder with cognitive and cortical alterations in Schizophrenia patients.European child & adolescent psychiatry · 2025Article
- The Multidimensional Dynamic Feedback Model: A Comprehensive Framework for Understanding and Managing Attention-Deficit/Hyperactivity Disorder.Children (Basel, Switzerland) · 2025Review
- Connectome-based symptom mapping andmedRxiv : the preprint server for health sciences · 2024Article
- Harnessing mega-analysis in the era of "big data" neuroimaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Cumulative Effects of Resting-State Connectivity Across All Brain Networks Significantly Correlate with Attention-Deficit Hyperactivity Disorder Symptoms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children.Journal of xenobiotics · 2024Article
- Potential Mechanisms Underlying Suicidality in Autistic People with Attention Deficit/Hyperactivity Disorder: Testing Hypotheses from the Interpersonal Theory of Suicide.Autism in adulthood · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
80 authors at 20 institutions in 16 countries.
Martine HoogmanDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1261-7628
Daan van RooijDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Marieke KleinDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Premika BoedhoeDepartment of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Iva IlioskaDepartment of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Ting LiDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Yash PatelBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Merel C PostemaDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Yanli Zhang-JamesDepartment of Psychiatry and behavioral sciences, SUNY Upstate Medical University, Syracuse, New York, USA.
Evdokia AnagnostouDepartment of Pediatrics University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
Guillaume AuziasINT UMR 7289, Aix-Marseille Université, CNRS, France.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Claiton H D BauDepartment of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Marlene BehrmannDepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Mark A BellgroveTurner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Silvia BremDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Geraldo F BusattoLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Sara CalderoniDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Pisa, Italy.
Rosa CalvoIDIBAPS, Barcelona, Spain.
Francisco X CastellanosDepartment of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York, New York, USA.
David CoghillDepartment of Paediatrics and Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
Annette ConzelmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Psychiatry and Psychotherapy, Tübingen, Germany.
Eileen DalyDepartment of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Christine DeruelleINT UMR 7289, Aix-Marseille Université, CNRS, France.
Ilan DinsteinDepartment of Psychology, Ben Gurion University, Beer Sheva, Israel.
Sarah DurstonNICHE lab, Deptartment of Psychiatry, UMC Utrecht Brain Center, Utrecht, The Netherlands.
Christine EckerDepartment of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Stefan EhrlichDivision of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technischen Universität Dresden, Dresden, Germany.
Jeffery N EpsteinDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Damien A FairDepartment of Psychiatry, Oregon Health & Science University, Portland, Oregon, USA.
Jacqueline FitzgeraldDepartment of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-6553-4378
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Center of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Thomas FrodlDepartment of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0002-8113-6959
Louise GallagherDepartment of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Eugenio H GrevetAdulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Jan HaavikK.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joost JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
Georgii KarkashadzeScientific research institute of Pediatrics and child health of Central clinical Hospital RAoS, Moscow, Russia.
Joseph A KingDivision of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technischen Universität Dresden, Dresden, Germany.
Kerstin KonradChild Neuropsychology Section, University Hospital RWTH Aachen, Aachen, Germany.
Jonna KuntsiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic, Barcelona, Spain.
Jason P LerchWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department for Clinical Neurosciences, University of Oxford, UK.
Klaus-Peter LeschDivision of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Mario R LouzaDepartment and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paulo MattosD'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Jane McGrathDepartment of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Filippo MuratoriDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Pisa, Italy.
Clodagh MurphyDepartment of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-6350-0155
Joel T NiggDepartment of Psychiatry, Oregon Health & Science University, Portland, Oregon, USA.
Eileen Oberwelland-WeissJARA Institute Molecular Neuroscience and Neuroimaging (INM-11), Institute for Neuroscience and Medicine, Research Center Jülich, Julich, Germany.
Ruth L O'Gorman TuuraCenter for MR Research, University Children's Hospital, Zurich, Switzerland.
Kirsten O'HearnDepartment of physiology and pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jaap OosterlaanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Mara ParelladaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
Paul PauliDepartment of Biological Psychology, Clinical Psychology and Psychotherapy, Würzburg, Germany.
Kerstin J PlessenChild and Adolescent Mental Health Centre, Copenhagen, Denmark.
J Antoni Ramos-QuirogaBiomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Liesbeth RenemanDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Alessandra ReticoNational Institute for Nuclear Physics, Pisa, Italy.ORCID 0000-0001-5135-4472
Pedro G P RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Katya RubiaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-1410-7701
Philip ShawNational Human Genome Research Institute, Bethesda, Maryland, USA.
Tim J SilkMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
Leanne TammDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Oscar VilarroyaDepartment of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Neda JahanshadImaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
Stephen V FaraoneDepartment of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, USA.
Clyde FrancksDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-9098-890X
Odile A van den HeuvelDepartment of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-9804-7653
Tomas PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
Jan K BuitelaarDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Barbara FrankeDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLKing's College London · GBTrinity College Dublin · IEGoethe University Frankfurt · DEUniversity of Toronto · CAUniversity of Zurich · CHAmsterdam Neuroscience · NLCentre National de la Recherche Scientifique · FRCincinnati Children's Hospital Medical Center · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRMarina Del Rey Hospital · USOregon Health & Science University · USSUNY Upstate Medical University · USTechnische Universität Dresden · DEUniversidad Complutense de Madrid · ESUniversidade Federal do Rio Grande do Sul · BRUniversitat Autònoma de Barcelona · ESUniversity of Pisa · ITAmsterdam University Medical Centers · NLBen-Gurion University of the Negev · IL
Funding
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MInternational Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2MBrain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8MMedical Research Council G0300189NIBIB NIH HHS U54 EB020403NIDA NIH HHS U01 DA041148NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH115357NIMH NIH HHS R01MH115357NIMH NIH HHS R01MH62873
Abstract
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
Indexed as
Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderBrainNeuroimagingHumansMulticenter Studies as TopicNeurosciencesADHDASDcortexENIGMAneuroimagingsubcortical volumes
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What Socratic holds
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LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.