Evidence map›Paper›PMID 32424795›Full record

ReviewAnalytical and bioanalytical chemistry2020

Nanoelectrochemistry in the study of single-cell signaling.

Ran Chen, Kristen Alanis, Theresa M Welle, Mei Shen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Trends in single-impact electrochemistry for bacteria analysis.Analytical and bioanalytical chemistry · 2023
    Review
  6. Review
  7. A subcellular cookie cutter for spatial genomics in human tissue.Analytical and bioanalytical chemistry · 2022
    Article
  8. Article
  9. Review
  10. ABC Spotlight on single-molecule detection.Analytical and bioanalytical chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ran ChenDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Kristen AlanisDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Theresa M WelleDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Mei ShenDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA. mshen233@illinois.edu.
University of Illinois Urbana-Champaign · US

Funding

Study Exocytosis in the Region of Synaptic Cleft using Electrochemical NanoprobeR21NS085665 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SHEN, MEI · 2013 to 2014
$391k
National Science Foundation CHE 19-45274NINDS NIH HHS R21NS085665
6 · The paper itself

Abstract

Label-free biosensing has been the dream of scientists and biotechnologists as reported by Vollmer and Arnold (Nat Methods 5:591-596, 2008). The ability of examining living cells is crucial to cell biology as noted by Fang (Int J Electrochem 2011:460850, 2011). Chemical measurement with electrodes is label-free and has demonstrated capability of studying living cells. In recent years, nanoelectrodes of different functionality have been developed. These nanometer-sized electrodes, coupled with scanning electrochemical microscopy (SECM), have further enabled nanometer spatial resolution study in aqueous environments. Developments in the field of nanoelectrochemistry have allowed measurement of signaling species at single cells, contributing to better understanding of cell biology. Leading studies using nanoelectrochemistry of a variety of cellular signaling molecules, including redox-active neurotransmitter (e.g., dopamine), non-redox-active neurotransmitter (e.g., acetylcholine), reactive oxygen species (ROS), and reactive nitrogen species (RNS), are reviewed here.

Indexed as

NanotechnologySignal TransductionCell Line, TumorElectrochemical TechniquesHumansNeurotransmitter AgentsOxidation-ReductionReactive Nitrogen SpeciesReactive Oxygen SpeciesSingle-Cell AnalysisNeurotransmitter AgentsReactive Nitrogen SpeciesReactive Oxygen SpeciesNanoelectrochemistryNanoelectrodeNeurotransmittersROS/RNSSingle cell

Identifiers

PMID32424795
OpenAlexW3027521749

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.