Evidence map›Paper›PMID 32430227›Full record

ReviewTrends in biotechnology2020

Microfluidics in Single-Cell Virology: Technologies and Applications.

Wu Liu, Hongzhang He, Si-Yang Zheng

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wu LiuDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: wuliu@andrew.cmu.edu.
Hongzhang HeCaptis Diagnostics Inc., Pittsburgh, PA 15213, USA.
Si-Yang ZhengDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: siyangzheng@cmu.edu.

Funding

Carbon nanotube integrated microdevice for next generation sequencing based virus discoveryR01AI134911 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHENG, SIYANG · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI134911
6 · The paper itself

Abstract

Microfluidics has proven to be a powerful tool for probing biology at the single-cell level. However, it is only in the past 5 years that single-cell microfluidics has been used in the field of virology. An array of strategies based on microwells, microvalves, and droplets is now available for tracking viral infection dynamics, identifying cell subpopulations with particular phenotypes, as well as high-throughput screening. The insights into the virus-host interactions gained at the single-cell level are unprecedented and usually inaccessible by population-based experiments. Therefore, single-cell microfluidics, which opens new avenues for mechanism elucidation and development of antiviral therapeutics, would be a valuable tool for the study of viral pathogenesis.

Indexed as

MicrofluidicsSingle-Cell AnalysisVirologyHigh-Throughput Screening Assaysheterogeneitymicrofluidicssingle-cell analysistranscriptomic analysisviral infection dynamicsvirology

Identifiers

PMID32430227
PMCPMC8942716

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.