Evidence map›Paper›PMID 32432881›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2020

γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.

Marilia Barros, William J Houlihan, Chelsea J Paresi, Matthew Brendel, Kevin D Rynearson, Chang-Wook Lee, Olga Prikhodko, Cristina Cregger, Geoffrey Chang, Steven L Wagner and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Marilia BarrosChemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.
William J HoulihanDepartment of Chemical Engineering and the Department of Biomedical Engineering, The City College of the City University of New York, New York, New York 10031, United States.
Chelsea J ParesiChemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.
Matthew BrendelMolecular Cytology Core, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.
Kevin D RynearsonDepartment of Neurosciences, University of California, San Diego, California 92093, United States.
Chang-Wook Lee
Olga PrikhodkoDepartment of Neurosciences, University of California, San Diego, California 92093, United States.
Cristina CreggerDepartment of Neurosciences, University of California, San Diego, California 92093, United States.
Geoffrey Chang
Steven L WagnerDepartment of Neurosciences, University of California, San Diego, California 92093, United States.
M Lane GilchristDepartment of Chemical Engineering and the Department of Biomedical Engineering, The City College of the City University of New York, New York, New York 10031, United States.ORCID 0000-0002-6247-5787
Yue-Ming LiChemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0002-2633-3730
University of California San Diego · USMemorial Sloan Kettering Cancer Center · USCity College of New York · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Bao Q Vuong · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
VOLTAGE GATING OF ION CHANNELS--SIMULATIONS AND AB INITIO CALCULATIONSS06GM008168 · NIGMS · CITY COLLEGE OF NEW YORK · PI GILCHRIST, M LANE · 1989 to 2010
$17.6M
Regulation of y-secretase activity by modulatory proteinsR01AG061350 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2019 to 2023
$4.3M
Substrate Feedback Mechanism of gamma-SecretaseRF1AG057593 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2018 to 2018
$2.1M
Mechanism and Synergy of gamma-Secretase ModulatorsR01NS096275 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2016 to 2020
$2.1M
NCI NIH HHS P30 CA008748NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NIA NIH HHS R01 AG061350NIA NIH HHS RF1 AG057593NIGMS NIH HHS S06 GM008168NINDS NIH HHS R01 NS096275
6 · The paper itself

Abstract

γ-Secretase is a multisubunit complex that catalyzes intramembranous cleavage of transmembrane proteins. The lipid environment forms membrane microdomains that serve as spatio-temporal platforms for proteins to function properly. Despite substantial advances in the regulation of γ-secretase, the effect of the local membrane lipid microenvironment on the regulation of γ-secretase is poorly understood. Here, we characterized and quantified the partitioning of γ-secretase and its substrates, the amyloid precursor protein (APP) and Notch, into lipid bilayers using solid-supported model membranes. Notch substrate is preferentially localized in the liquid-disordered (L

Indexed as

Amyloid Precursor Protein SecretasesLipid BilayersAmyloid beta-Protein PrecursorMembrane LipidsMembrane MicrodomainsAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesLipid BilayersMembrane Lipids

Identifiers

PMID32432881
PMCPMC7887708
OpenAlexW3027042770

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.