ReviewTobacco induced diseases2020
Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity.
Review in Tobacco induced diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- An Umbrella Review of E-Cigarettes' Impact on Oral Microbiota and Biofilm Buildup.Pathogens (Basel, Switzerland) · 2025Pooled it
- Association of electronic cigarette use and suicidal behaviors: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- The effect of nicotine delivery system on blood protease levels: a randomized crossover study.Scientific reports · 2025Trial
- Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026Review
- Electronic cigarette use and risk of incident rheumatoid arthritis and systemic lupus erythematosus in the all of us research program.Seminars in arthritis and rheumatism · 2026Article
- Article
- Subgingival Microbiome in Young Adult Cigarette Smokers, E-Cigarette Users, and Non-Smokers.Medicina (Kaunas, Lithuania) · 2026Article
- E-cigarettes and erectile dysfunction: biological mechanisms and research challenges.International journal of impotence research · 2026Review
- Knowledge, Attitude, and Use of E-Cigarettes Among Syrian University Students: A Cross-Sectional Study.Health science reports · 2026Article
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Health warnings for electronic cigarette packaging: a rapid scoping review.BMC public health · 2026Article
- Salivary Proteomics Reveals Oxidative Markers in E-Cigarette Users.Journal of proteome research · 2026Article
- Differences in e-cigarette use, dependence, and knowledge between health and social sciences university students in Costa Rica.Frontiers in oral health · 2026Article
- From bugs to behavior: targeting the gut-brain interface for addiction therapeutics.Gut microbes · 2025Review
- Selected Population-based Oral Health Assessment Following Usage of E-Cigarettes and Combustible Cigarettes.Oral health & preventive dentistry · 2025Article
- The respiratory epithelium in the era of vaping: insights fromEuropean respiratory review : an official journal of the European Respiratory Society · 2025Review
- Vitamins C and E alleviate the deleterious effects of electronic cigarettes on tongue muscles and nerves in rat model.BMC oral health · 2025Article
- Therapeutic effects of single-clove garlic extract on nicotine-induced inflammation and histopathological changes in rats.Open veterinary journal · 2025Review
- Assessing Nicotine Exposure in Users and Non-Users of Electronic Cigarettes Through Silicone Wristbands.International journal of environmental research and public health · 2025Article
- Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products-A Narrative Review.International journal of molecular sciences · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Use of electronic nicotine delivery systems (ENDS), such as electronic cigarettes (e-cigs), is increasing across the US population and is particularly troubling due to their adoption by adolescents, teens, and young adults. The industry's marketing approach for these instruments of addiction has been to promote them as a safer alternative to tobacco, a behavioral choice supporting smoking cessation, and as the 'cool' appearance of vaping with flavored products (e.g. tutti frutti, bubble gum, and buttered popcorn etc.). Thus, there is a clear need to better document the health outcomes of e-cig use in the oral cavity of the addicted chronic user. There appears to be an array of environmental toxins in the vapors, including reactive aldehydes and carbonyls resulting from the heating elements action on fluid components, as well as from the composition of chemical flavoring agents. The chemistry of these systems shows that the released vapors from the e-cigs frequently contain levels of environmental toxins that considerably exceed federal occupational exposure limits. Additionally, the toxicants in the vapors appear to be retained in the host fluids/tissues at levels often approximating 90% of the levels in the e-cig vapors. These water-soluble reactive toxins can challenge the oral cavity constituents, potentially contributing to alterations in the autochthonous microbiome and host cells critical for maintaining oral homeostasis. This review updates the existing chemistry/environmental aspects of e-cigs, as well as providing an overview of the somewhat limited data on potential oral health effects that could occur across the lifetime of daily e-cig users.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.