Evidence map›Paper›PMID 32435383›Full record

ArticleACS medicinal chemistry letters2020

5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.

Savina Malancona, Mattia Mori, Paola Fezzardi, Marisabella Santoriello, Andreina Basta, Martina Nibbio, Lesia Kovalenko, Roberto Speziale, Maria Rosaria Battista, Antonella Cellucci and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Active Components fromInternational journal of molecular sciences · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 2 countries.

Savina MalanconaIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
Paola FezzardiIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Marisabella SantorielloIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Andreina BastaIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Martina NibbioIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Lesia KovalenkoLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
Roberto SpezialeIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Maria Rosaria BattistaIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Antonella CellucciIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Nadia GennariIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Edith MonteagudoIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Annalise Di MarcoIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Alessia GianniniDepartment of Medical Biotechnologies, University of Siena, Viale Mario Bracci, 16, 50100 Siena, Italy.
Rajhans SharmaLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
Manuel PiresLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
Eleonore RealLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
Maurizio ZazziDepartment of Medical Biotechnologies, University of Siena, Viale Mario Bracci, 16, 50100 Siena, Italy.
Maria Chiara Dasso LangDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
Davide De ForniViroStatics S.r.l, Viale Umberto I 46, 07100 Sassari, Italy.
Francesco SaladiniDepartment of Medical Biotechnologies, University of Siena, Viale Mario Bracci, 16, 50100 Siena, Italy.
Yves MelyLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 Route du Rhin, 67401 Illkirch, France.
Vincenzo SummaIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Steven HarperIRBM S.p.A., Via Pontina Km 30.600, 00071 Pomezia, Rome, Italy.
Maurizio BottaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
IRBM Science Park · ITUniversity of Siena · ITCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly conserved sequence offers the opportunity to escape the drug resistance (DR) that emerged following the highly active antiretroviral therapy (HAART) treatment. On the basis of our previous research, nordihydroguaiaretic acid

Identifiers

PMID32435383
PMCPMC7236274
OpenAlexW3010813411

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.