ArticleMolecular biology and evolution2020
The Neandertal Progesterone Receptor.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Progesterone Receptor Gene Polymorphisms and Breast Cancer Risk.Endocrinology · 2023Pooled it
- An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species.Frontiers in genome editing · 2026Review
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- Chromosome-Level Genome Assembly of the Meishan Pig and Insights into Its Domestication Mechanisms.Animals : an open access journal from MDPI · 2025Article
- The trait-specific timing of accelerated genomic change in the human lineage.Cell genomics · 2025Article
- The hormonal control of parturition.Physiological reviews · 2024Review
- Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent.Human genomics · 2023Article
- Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals.Molecular biology and evolution · 2023Article
- The 2022 nobel prize in physiology or medicine awarded for the decoding of the complete ancient human genome.Biomedical journal · 2023Article
- Prevention of Pregnancy Loss: Combining Progestogen Treatment and Psychological Support.Journal of clinical medicine · 2023Review
- Predicting Archaic Hominin Phenotypes from Genomic Data.Annual review of genomics and human genetics · 2022Review
- Nuclear Progestin Receptor-mediated Linkage of Blood Coagulation and Ovulation.Endocrinology · 2022Article
- Apportioning archaic variants among modern populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Review
- Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.BMC biology · 2022Article
- ABO Genetic Variation in Neanderthals and Denisovans.Molecular biology and evolution · 2021Article
- Our Tangled Family Tree: New Genomic Methods Offer Insight into the Legacy of Archaic Admixture.Genome biology and evolution · 2021Review
- The influence of evolutionary history on human health and disease.Nature reviews. Genetics · 2021Review
- A genomic region associated with protection against severe COVID-19 is inherited from Neandertals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Quantitative Human Paleogenetics: What can Ancient DNA Tell us About Complex Trait Evolution?Frontiers in genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element. These Neandertal gene variants have reached nearly 20% frequency in non-Africans and have been associated with preterm birth. Here, we show that one of the missense substitutions appears fixed in Neandertals, while the other substitution as well as the Alu insertion were polymorphic among Neandertals. We show that two Neandertal haplotypes carrying the PGR gene entered the modern human population and that present-day carriers of the Neandertal haplotypes express higher levels of the receptor. In a cohort of present-day Britons, these carriers have more siblings, fewer miscarriages, and less bleeding during early pregnancy suggesting that the Neandertal progesterone receptor alleles promote fertility. This may explain their high frequency in modern human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.