Evidence map›Paper›PMID 32438620›Full record

ReviewNutrients2020

COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation.

Ioannis Zabetakis, Ronan Lordan, Catherine Norton, Alexandros Tsoupras

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 7 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 7 syntheses or guidelines pooled it, 540 citations in OpenAlex.

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200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ioannis ZabetakisDepartment of Biological Sciences, University of Limerick, Limerick V94 T9PX, Ireland.ORCID 0000-0001-8175-950X
Ronan LordanHealth Research Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID 0000-0001-9668-3368
Catherine NortonHealth Research Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID 0000-0001-8973-6759
Alexandros TsouprasDepartment of Biological Sciences, University of Limerick, Limerick V94 T9PX, Ireland.ORCID 0000-0002-0837-9778
University of Limerick · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable economic distress globally and a significant loss of life. Sadly, the vulnerable and immunocompromised in our societies seem to be more susceptible to severe COVID-19 complications. Global public health bodies and governments have ignited strategies and issued advisories on various handwashing and hygiene guidelines, social distancing strategies, and, in the most extreme cases, some countries have adopted "stay in place" or lockdown protocols to prevent COVID-19 spread. Notably, there are several significant risk factors for severe COVID-19 infection. These include the presence of poor nutritional status and pre-existing noncommunicable diseases (NCDs) such as diabetes mellitus, chronic lung diseases, cardiovascular diseases (CVD), obesity, and various other diseases that render the patient immunocompromised. These diseases are characterized by systemic inflammation, which may be a common feature of these NCDs, affecting patient outcomes against COVID-19. In this review, we discuss some of the anti-inflammatory therapies that are currently under investigation intended to dampen the cytokine storm of severe COVID-19 infections. Furthermore, nutritional status and the role of diet and lifestyle is considered, as it is known to affect patient outcomes in other severe infections and may play a role in COVID-19 infection. This review speculates the importance of nutrition as a mitigation strategy to support immune function amid the COVID-19 pandemic, identifying food groups and key nutrients of importance that may affect the outcomes of respiratory infections.

Indexed as

BetacoronavirusNutritional StatusAnti-Inflammatory AgentsCoronavirus InfectionsCOVID-19CytokinesDietHumansInflammationNutrition TherapyPandemicsPneumonia, ViralSARS-CoV-2Anti-Inflammatory AgentsCytokinesanti-inflammatorycoronavirusCOVID-19infectioninflammationnoncommunicable diseasesnutritionSARS-CoV-2vitamin Cvitamin Dzinc

Identifiers

PMID32438620
PMCPMC7284818
OpenAlexW3028130826

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.