Evidence map›Paper›PMID 32440710›Full record

ArticleCellular and molecular life sciences : CMLS2021

Studies of ApoD

Nicole El-Darzi, Natalia Mast, Alexey M Petrov, Tung Dao, Artem A Astafev, Aicha Saadane, Erin Prendergast, Emmy Schwarz, Ilya Bederman, Irina A Pikuleva

Open access · goldAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  12. Review
  13. Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicole El-DarziDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
Natalia MastDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-6427-640X
Alexey M PetrovDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1432-3455
Tung DaoDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
Artem A AstafevDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
Aicha SaadaneDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
Erin PrendergastDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Emmy SchwarzDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Ilya BedermanDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Irina A PikulevaDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA. iap8@case.edu.ORCID http://orcid.org/0000-0001-9742-6232
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Significance of CYP46A1 and other P450s in retinal functionR01EY018383 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PIKULEVA, IRINA A · 2007 to 2024
$6.8M
NEI NIH HHS EY011373NEI NIH HHS EY018383NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY018383
6 · The paper itself

Abstract

Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport. Herein, we immunolocalized APOD to the photoreceptor inner segments and conducted ophthalmic characterizations of ApoD

Indexed as

AnimalsApolipoproteins DApolipoproteins ECD36 AntigensDiet, High-FatFatty AcidsFemaleGenotypeGlucoseGlucose Transporter Type 4Isotope LabelingMaleMiceMice, Inbred C57BLMice, KnockoutProteomicsApolipoproteins DApolipoproteins ECD36 AntigensCd36 protein, mouseFatty AcidsGlucoseGlucose Transporter Type 4Slc2a4 protein, mouseSterolsApolipoproteinCholesterolFatty acidsGlucoseIsotopic labelingLeptin receptor

Identifiers

PMID32440710
PMCPMC7679289
OpenAlexW3026264516

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.